Deep learning approach for differentiating indeterminate adrenal masses using CT imaging.
Purpose: Distinguishing stage 1–2 adrenocortical carcinoma (ACC) and large, lipid poor adrenal adenoma (LPAA) via imaging is challenging due to overlapping imaging characteristics. This study investigated the ability of deep learning to distinguish ACC and LPAA on single time-point CT images. Method...
| Publicado en: | Abdominal Radiology Vol. 48; no. 10; pp. 3189 - 3195 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171388145&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171388145 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Oct2023 vid: 48 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 171388145 164568919 10.1007/s00261-023-03988-w 171388145 ppf: 3189 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Deep learning approach for differentiating indeterminate adrenal masses using CT imaging. aug: au: Singh, Yashbir Kelm, Zachary S. Faghani, Shahriar Erickson, Dana Yalon, Tal Bancos, Irina Erickson, Bradley J. affil: Department of Radiology, Mayo Clinic, Rochester, MN, USA sug: ab: Purpose: Distinguishing stage 1–2 adrenocortical carcinoma (ACC) and large, lipid poor adrenal adenoma (LPAA) via imaging is challenging due to overlapping imaging characteristics. This study investigated the ability of deep learning to distinguish ACC and LPAA on single time-point CT images. Methods: Retrospective cohort study from 1994 to 2022. Imaging studies of patients with adrenal masses who had available adequate CT studies and histology as the reference standard by method of adrenal biopsy and/or adrenalectomy were included as well as four patients with LPAA determined by stability or regression on follow-up imaging. Forty-eight (48) subjects with pathology-proven, stage 1–2 ACC and 43 subjects with adrenal adenoma >3 cm in size demonstrating a mean non-contrast CT attenuation > 20 Hounsfield Units centrally were included. We used annotated single time-point contrast-enhanced CT images of these adrenal masses as input to a 3D Densenet121 model for classifying as ACC or LPAA with five-fold cross-validation. For each fold, two checkpoints were reported, highest accuracy with highest sensitivity (accuracy focused) and highest sensitivity with the highest accuracy (sensitivity focused). Results: We trained a deep learning model (3D Densenet121) to predict ACC versus LPAA. The sensitivity-focused model achieved mean accuracy: 87.2% and mean sensitivity: 100%. The accuracy-focused model achieved mean accuracy: 91% and mean sensitivity: 96%. Conclusion: Deep learning demonstrates promising results distinguishing between ACC and large LPAA using single time-point CT images. Before being widely adopted in clinical practice, multicentric and external validation are needed. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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