Prefrontal-cerebellar dynamics during post-success and post-error cognitive controls in major psychiatric disorders.
Background: Difficulty in cognitive adjustment after a conflict or error is a hallmark for many psychiatric disorders, yet the underlying neural correlates are not fully understood. We have previously shown that post-success and post-error cognitive controls are associated with distinct mechanisms p...
| Publicado en: | Psychological Medicine Vol. 53; no. 11; pp. 4915 - 4923 |
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| Autor principal: | |
| Formato: | pictorial research tables/charts Journal Article |
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Cambridge University Press
Aug2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171577626&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171577626 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Aug2023 vid: 53 iid: 11 pid: 15979 pub: Cambridge University Press artinfo: ui: 171577626 171577626 171577626 10.1017/S0033291722001829 171577626 ppf: 4915 ppct: 8 formats: tig: atl: Prefrontal-cerebellar dynamics during post-success and post-error cognitive controls in major psychiatric disorders. aug: au: Cao, Hengyi affil: Center for Psychiatric Neuroscience, Feinstein Institutes for Medical Research, Manhasset, NY, USA sug: subj: Prefrontal Cortex Physiology Cerebellum Radiography Mental Disorders Executive Function Psychomotor Performance Task Performance and Analysis Cognition Disorders Brain Radiography Attention Deficit Hyperactivity Disorder Diagnosis Brain Mapping Methods Schizophrenia Diagnosis Bipolar Disorder Diagnosis Magnetic Resonance Imaging Causal Modeling Brain Physiopathology Human Male Female Young Adult Adult Middle Age Data Analysis Software Motor Skills Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Difficulty in cognitive adjustment after a conflict or error is a hallmark for many psychiatric disorders, yet the underlying neural correlates are not fully understood. We have previously shown that post-success and post-error cognitive controls are associated with distinct mechanisms particularly related to the prefrontal-cerebellar circuit, raising the possibility that altered dynamic interactions in this circuit may underlie mental illness. Methods: This study included 136 patients with three diagnosed disorders [48 schizophrenia (SZ), 49 bipolar disorder (BD), 39 attention deficit hyperactivity disorder (ADHD)] and 89 healthy controls who completed a stop-signal task during fMRI scans. Brain activations for concurrent, post-success, and post-error cognitive controls were analyzed and compared between groups. Dynamic causal modeling was applied to investigate prefrontal-cerebellar effective connectivity patterns during post-success and post-error processing. Results: No significant group differences were observed for brain activations and overall effective connectivity structures during post-success and post-error conditions. However, significant group differences were shown for the modulational effect on top-down connectivity from the prefrontal cortex to the cerebellum during post-error trials (pFWE = 0.02), which was driven by reduced modulations in both SZ and ADHD. During post-success trials, there were significantly decreased modulational effect on bottom-up connectivity from the cerebellum to the prefrontal cortex in ADHD (pFWE = 0.04) and decreased driving input to the cerebellum in SZ (pFWE = 0.04). Conclusions: These findings suggest that patients with SZ and ADHD are associated with insufficient neural modulation on the prefrontal-cerebellar circuit during post-success and post-error cognitive processing, a phenomenon that may underlie cognitive deficits in these disorders. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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