Improving accuracy in diagnosing aortic stenosis severity: An in‐depth analysis of echocardiographic measurement error through literature review and simulation study.

Aims: The present guidelines advise replacing the aortic valve for individuals with severe aortic stenosis (AS) based on various echocardiographic parameters. Accurate measurements are essential to avoid misclassification and unnecessary interventions. The objective of this study was to evaluate the...

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Publicado en:Echocardiography Vol. 40; no. 9; pp. 892 - 903
Autores principales: Velders, Bart J. J., Groenwold, Rolf H. H., Ajmone Marsan, Nina, Kappetein, Arie‐Pieter, Wijngaarden, Rob A. F. De Lind Van, Braun, Jerry, Klautz, Robert J. M., Vriesendorp, Michiel D.
Formato: diagnostic images equations & formulas review tables/charts Journal Article
Publicado: Wiley-Blackwell Sep2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Sep2023
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1111/echo.15664
        171810290
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        atl: Improving accuracy in diagnosing aortic stenosis severity: An in‐depth analysis of echocardiographic measurement error through literature review and simulation study.
      aug:
        au:
          Velders, Bart J. J.
          Groenwold, Rolf H. H.
          Ajmone Marsan, Nina
          Kappetein, Arie‐Pieter
          Wijngaarden, Rob A. F. De Lind Van
          Braun, Jerry
          Klautz, Robert J. M.
          Vriesendorp, Michiel D.
        affil: Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
      sug:
        subj:
          Aortic Valve Stenosis Diagnosis
          Validity
          Echocardiography Methods
          Measurement Error
          Simulations
          Decision Making, Clinical
          Interrater Reliability
          Severity of Illness
          Diagnostic Errors
      ab: Aims: The present guidelines advise replacing the aortic valve for individuals with severe aortic stenosis (AS) based on various echocardiographic parameters. Accurate measurements are essential to avoid misclassification and unnecessary interventions. The objective of this study was to evaluate the influence of measurement error on the echocardiographic evaluation of the severity of AS. Methods and results: A systematic review was performed to examine whether measurement errors are reported in studies focusing on the prognostic value of peak aortic jet velocity (Vmax), mean pressure gradient (MPG), and effective orifice area (EOA) in asymptomatic patients with AS. Out of the 37 studies reviewed, 17 (46%) acknowledged the existence of measurement errors, but none of them utilized methods to address them. Secondly, the magnitude of potential errors was collected from available literature for use in clinical simulations. Interobserver variability ranged between 0.9% and 8.3% for Vmax and MPG but was higher for EOA (range 7.7%‐12.7%), indicating lower reliability. Assuming a circular left ventricular outflow tract area led to a median underestimation of EOA by 23% compared to planimetry by other modalities. A clinical simulation resulted in the reclassification of 42% of patients, shifting them from a diagnosis of severe AS to moderate AS. Conclusions: Measurement errors are underreported in studies on echocardiographic assessment of AS severity. These errors can lead to misclassification and misdiagnosis. Clinicians and scientists should be aware of the implications for accurate clinical decision‐making and assuring research validity.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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