Magnetic resonance imaging-derived parameters to predict response to regorafenib in recurrent glioblastoma.
Purpose: Regorafenib is a multikinase inhibitor, approved as a preferred regimen for recurrent glioblastoma (rGB). Although its effects on prolonging survival could seem modest, it is still unclear whether a subset of patients, potentially identifiable by imaging biomarkers, might experience a more...
| Publicado en: | Neuroradiology Vol. 65; no. 10; pp. 1439 - 1446 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171898840&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171898840 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2023 vid: 65 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 171898840 163962469 171898840 171898840 10.1007/s00234-023-03169-y 171898840 ppf: 1439 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Magnetic resonance imaging-derived parameters to predict response to regorafenib in recurrent glioblastoma. aug: au: Martucci, Matia Ferranti, Andrea Maurizio Schimperna, Francesco Infante, Amato Magnani, Francesca Olivi, Alessandro D'Alessandris, Quintino Giorgio Gessi, Marco Chiesa, Silvia Mazzarella, Ciro Russo, Rosellina Giordano, Carolina Gaudino, Simona affil: UOSD Neuroradiologia Diagnostica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del S. Cuore, Largo A. Gemelli, 8, 00168, Rome, Italy sug: subj: Glioma Drug Therapy Neoplasm Recurrence, Local Drug Therapy Glioma Prognosis Neoplasm Recurrence, Local Prognosis Tyrosine Kinase Inhibitors Therapeutic Use Antineoplastic Agents Therapeutic Use Tumor Markers, Biological Analysis Magnetic Resonance Imaging Neuroradiography Human Cancer Patients Cerebral Blood Volume Progression-Free Survival Overall Survival Survival Analysis Descriptive Statistics Comparative Studies Treatment Outcomes ab: Purpose: Regorafenib is a multikinase inhibitor, approved as a preferred regimen for recurrent glioblastoma (rGB). Although its effects on prolonging survival could seem modest, it is still unclear whether a subset of patients, potentially identifiable by imaging biomarkers, might experience a more substantial positive effect. Our aim was to evaluate the potential value of magnetic resonance imaging-derived parameters as non-invasive biomarkers to predict response to regorafenib in patients with rGB. Methods: 20 patients with rGB underwent conventional and advanced MRI at diagnosis (before surgery), at recurrence and at first follow-up (3 months) during regorafenib. Maximum relative cerebral blood volume (rCBVmax) value, intra-tumoral susceptibility signals (ITSS), apparent diffusion coefficient (ADC) values, and contrast-enhancing tumor volumes were tested for correlation with response to treatment, progression-free survival (PFS), and overall survival (OS). Response at first follow-up was assessed according to Response Assessment in Neuro-Oncology (RANO) criteria. Results: 8/20 patients showed stable disease at first follow-up. rCBVmax values of the primary glioblastoma (before surgery) significantly correlated to treatment response; specifically, patients with stable disease displayed higher rCBVmax compared to progressive disease (p = 0.04, 2-group t test). Moreover, patients with stable disease showed longer PFS (p = 0.02, 2-group t test) and OS (p = 0.04, 2-group t test). ITSS, ADC values, and contrast-enhancing tumor volumes showed no correlation with treatment response, PFS nor OS. Conclusion: Our results suggest that rCBVmax of the glioblastoma at diagnosis could serve as a non-invasive biomarker of treatment response to regorafenib in patients with rGB. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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