Association between resistance to cerebrospinal fluid flow and cardiac-induced brain tissue motion for Chiari malformation type I.
Purpose: Chiari malformation type I (CMI) patients have been independently shown to have both increased resistance to cerebrospinal fluid (CSF) flow in the cervical spinal canal and greater cardiac-induced neural tissue motion compared to healthy controls. The goal of this paper is to determine if a...
| Publicado en: | Neuroradiology Vol. 65; no. 10; pp. 1535 - 1544 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171898849&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171898849 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2023 vid: 65 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 171898849 170898539 171898849 171898849 10.1007/s00234-023-03207-9 171898849 ppf: 1535 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between resistance to cerebrospinal fluid flow and cardiac-induced brain tissue motion for Chiari malformation type I. aug: au: Mohsenian, Saeed Ibrahimy, Alaaddin Al Samman, Mohamad Motaz F. Oshinski, John N. Bhadelia, Rafeeque A. Barrow, Daniel L. Allen, Philip A. Amini, Rouzbeh Loth, Francis affil: Department of Bioengineering, Northeastern University, 360 Huntington Ave, 02115, Boston, MA, USA sug: subj: Arnold-Chiari Malformation Complications Cerebrospinal Fluid Physiopathology Brain Physiopathology Risk Assessment Human Magnetic Resonance Imaging Correlational Studies Arnold-Chiari Malformation Symptoms Cerebellum Physiopathology Nerve Tissue Physiopathology Movement Evaluation Electric Impedance Funding Source ab: Purpose: Chiari malformation type I (CMI) patients have been independently shown to have both increased resistance to cerebrospinal fluid (CSF) flow in the cervical spinal canal and greater cardiac-induced neural tissue motion compared to healthy controls. The goal of this paper is to determine if a relationship exists between CSF flow resistance and brain tissue motion in CMI subjects. Methods: Computational fluid dynamics (CFD) techniques were employed to compute integrated longitudinal impedance (ILI) as a measure of unsteady resistance to CSF flow in the cervical spinal canal in thirty-two CMI subjects and eighteen healthy controls. Neural tissue motion during the cardiac cycle was assessed using displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) technique. Results: The results demonstrate a positive correlation between resistance to CSF flow and the maximum displacement of the cerebellum for CMI subjects (r = 0.75, p = 6.77 × 10−10) but not for healthy controls. No correlation was found between CSF flow resistance and maximum displacement in the brainstem for CMI or healthy subjects. The magnitude of resistance to CSF flow and maximum cardiac-induced brain tissue motion were not statistically different for CMI subjects with and without the presence of five CMI symptoms: imbalance, vertigo, swallowing difficulties, nausea or vomiting, and hoarseness. Conclusion: This study establishes a relationship between CSF flow resistance in the cervical spinal canal and cardiac-induced brain tissue motion in the cerebellum for CMI subjects. Further research is necessary to understand the importance of resistance and brain tissue motion in the symptomatology of CMI. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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