Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome.
Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit impaired ability to process and understand emotions in others. We measured structural connectivity in children and adolescents with 22q11.2DS (n = 28) and healthy controls (n = 29). Compared to controls, those with 22q11.2DS had...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 53; no. 10; pp. 4021 - 4035 |
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| Autores principales: | , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171915530&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171915530 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Oct2023 vid: 53 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 171915530 158313868 171915530 171915530 10.1007/s10803-022-05675-z 171915530 ppf: 4021 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome. aug: au: Sanders, Ashley F. P. Hobbs, Diana A. Knaus, Tracey A. Beaton, Elliott A. affil: Department of Psychology, University of New Orleans, 2000 Lakeshore Drive, 70148, New Orleans, LA, USA sug: subj: Brain Emotions DiGeorge Syndrome Physiopathology Chromosome Disorders 22q11 Deletion Syndrome In Adolescence 22q11 Deletion Syndrome In Infancy and Childhood Social Skills Human Chromosomes Mutation Funding Source Child Adolescence Comparative Studies White Matter Amygdala Temporal Lobe Biological Markers Face Perception Male Female Child: 6-12 years Adolescent: 13-18 years Male Female ab: Children with chromosome 22q11.2 deletion syndrome (22q11.2DS) exhibit impaired ability to process and understand emotions in others. We measured structural connectivity in children and adolescents with 22q11.2DS (n = 28) and healthy controls (n = 29). Compared to controls, those with 22q11.2DS had poorer social skills and more difficulty recognizing facial emotions. Children with 22q11.2DS also had higher fractional anisotropic diffusion in right amygdala to fusiform gyrus white matter pathways. Right amygdala to fusiform gyrus fractional anisotropy values partially mediated the relationship between 22q11.2DS and social skills, as well as the relationship between 22q11.2DS and emotion recognition accuracy. These findings provide insight into the neural origins of social skills deficits seen in 22q11.2DS and may serve as a biomarker for risk of future psychiatric problems. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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