Effect of a Multi-Ingredient Supplement Designed to Regulate Mood on Physiological and Psychological Outcomes: A Randomized, Double-Blind, Placebo-Controlled Trial.

Stress is inevitable in college, and many students utilize alternatives to professional help such as supplements to manage stress, anxiety, or depression. A randomized, double-blind, placebo-controlled trial was conducted to assess the effectiveness of a multi-ingredient supplement (MIS) in supporti...

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Publicado en:Journal of Dietary Supplements Vol. 20; no. 4; pp. 631 - 644
Autores principales: Brown, Ann F., Richardson, Clarissa M. E., Newby, Nathan, Pulsipher, Sydney, Hoenec, Talje
Formato: research tables/charts randomized controlled trial Journal Article
Publicado: Taylor & Francis Ltd 2023
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/19390211.2022.2077880
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        atl: Effect of a Multi-Ingredient Supplement Designed to Regulate Mood on Physiological and Psychological Outcomes: A Randomized, Double-Blind, Placebo-Controlled Trial.
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        au:
          Brown, Ann F.
          Richardson, Clarissa M. E.
          Newby, Nathan
          Pulsipher, Sydney
          Hoenec, Talje
        affil: Department of Movement Sciences, University of Idaho, Moscow, ID, USA
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        subj:
          Dietary Supplements Therapeutic Use
          Dietary Supplementation
          Affect Evaluation
          Stress, Psychological Prevention and Control
          Students, College Psychosocial Factors
          Stress Management Methods
          Treatment Outcomes
          Human
          Randomized Controlled Trials
          Random Assignment
          Double-Blind Studies
          Descriptive Statistics
          Hydrocortisone
          Male
          Female
          Analysis of Variance
          Funding Source
          Male
          Female
      ab: Stress is inevitable in college, and many students utilize alternatives to professional help such as supplements to manage stress, anxiety, or depression. A randomized, double-blind, placebo-controlled trial was conducted to assess the effectiveness of a multi-ingredient supplement (MIS) in supporting optimal mood balance and reducing daily stress among healthy collegiate-aged students (clinicaltrials.gov, NCT05109923). Participants (age 18-22) were randomly assigned to a placebo (PLA; n = 29) or MIS (n = 27) group and were asked to consume 2 capsules upon waking and before bed. Resting heart rate, blood pressure and salivary cortisol awakening response (CAR) were measured at weeks 2, 5 and 8. Depression, anxiety, stress, and affect were assessed weekly. There was a significant negative linear change in CAR, depression, stress, positive and negative affect throughout the study although only CAR differed by group. From week 2 to 5, MIS decreased, on average, from 0.22 µg/dL to 0.14 µg/dL (-0.8 µg/dL), whereas PLA, on average, increased from 0.11 µg/dL to 0.17 µg/dL. MIS continued to experience a decline in CAR, ending the study with an average CAR of 0.08 µg/dL. These results suggest that MIS may help maintain a healthy physiological response during stressful life events.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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