What Matters in Radiological Image Segmentation? Effect of Segmentation Errors on the Diagnostic Related Features.

Segmentation is a crucial step in extracting the medical image features for clinical diagnosis. Though multiple metrics have been proposed to evaluate the segmentation performance, there is no clear study on how or to what extent the segmentation errors will affect the diagnostic related features us...

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Publicado en:Journal of Digital Imaging Vol. 36; no. 5; pp. 2088 - 2100
Autores principales: Chen, Zihang, Chen, Jiafei, Zhao, Jun, Liu, Bowei, Jiang, Shuanglong, Si, Dongyue, Ding, Haiyan, Nian, Yongjian, Yang, Xiaochao, Xiao, Jingjing
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Oct2023
Acceso en línea:Ver este registro en EBSCOhost
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        atl: What Matters in Radiological Image Segmentation? Effect of Segmentation Errors on the Diagnostic Related Features.
      aug:
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          Chen, Zihang
          Chen, Jiafei
          Zhao, Jun
          Liu, Bowei
          Jiang, Shuanglong
          Si, Dongyue
          Ding, Haiyan
          Nian, Yongjian
          Yang, Xiaochao
          Xiao, Jingjing
        affil: https://ror.org/023rhb549 Bioengineering College, Chongqing University, Chongqing, China
      sug:
        subj:
          Image Processing, Computer Assisted
          User-Computer Interface
          Computer Graphics
          Diagnostic Imaging Evaluation
          Human
          Experimental Studies
          Algorithms
          Deep Learning
          Funding Source
          Magnetic Resonance Imaging Methods
          Radiology Information Systems
          Time Series
          T-Tests
          Descriptive Statistics
      ab: Segmentation is a crucial step in extracting the medical image features for clinical diagnosis. Though multiple metrics have been proposed to evaluate the segmentation performance, there is no clear study on how or to what extent the segmentation errors will affect the diagnostic related features used in clinical practice. Therefore, we proposed a segmentation robustness plot (SRP) to build the link between segmentation errors and clinical acceptance, where relative area under the curve (R-AUC) was designed to help clinicians to identify the robust diagnostic related image features. In experiments, we first selected representative radiological series from time series (cardiac first-pass perfusion) and spatial series (T2 weighted images on brain tumors) of magnetic resonance images, respectively. Then, dice similarity coefficient (DSC) and Hausdorff distance (HD), as the widely used evaluation metrics, were used to systematically control the degree of the segmentation errors. Finally, the differences between diagnostic related image features extracted from the ground truth and the derived segmentation were analyzed, using the statistical method large sample size T-test to calculate the corresponding p values. The results are denoted in the SRP, where the x-axis indicates the segmentation performance using the aforementioned evaluation metric, and the y-axis shows the severity of the corresponding feature changes, which are expressed in either the p values for a single case or the proportion of patients without significant change. The experimental results in SRP show that when DSC is above 0.95 and HD is below 3 mm, the segmentation errors will not change the features significantly in most cases. However, when segmentation gets worse, additional metrics are required for further analysis. In this way, the proposed SRP indicates the impact of the segmentation errors on the severity of the corresponding feature changes. By using SRP, one could easily define the acceptable segmentation errors in a challenge. Additionally, the R-AUC calculated from SRP provides an objective reference to help the selection of reliable features in image analysis.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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