Safety of troclosene sodium solution in decontamination of wounds: A prospective clinical and laboratory study.
Debate persists regarding the safety of hypochlorite‐containing solutions in the decontamination of infected wounds. In 2006, the Israeli Ministry of Health withdrew licensing approval for troclosene sodium as a wound irrigation solution. The aim of this prospective clinical and laboratory study was...
| Publicado en: | Wound Repair & Regeneration Vol. 31; no. 5; pp. 635 - 641 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep/Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=171961177&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 171961177 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Sep/Oct2023 vid: 31 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 171961177 164673811 171961177 171961177 10.1111/wrr.13105 171961177 ppf: 635 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Safety of troclosene sodium solution in decontamination of wounds: A prospective clinical and laboratory study. aug: au: Segal, Miriam Metanes, Issa O'Boyle, Ciaran P. Sadeh, Omer Hassan, Samer Bryzgalin, Leonid Lavi, Idit Franco, Eyal Har‐Shai, Yaron affil: Department of Plastic Surgery, The Lady Davis Carmel Medical Center, Haifa, Israel sug: subj: Wound Infection Drug Therapy Sodium Compounds Therapeutic Use Sodium Compounds Adverse Effects Drug Efficacy Evaluation Patient Safety Human Male Female Middle Age Aged Israel Prospective Studies Wound Care Descriptive Statistics Two-Tailed Test Pain Management Edema Erythema Granulation Tissue Exudates and Transudates Microbial Culture and Sensitivity Tests Wounds and Injuries Microbiology Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Debate persists regarding the safety of hypochlorite‐containing solutions in the decontamination of infected wounds. In 2006, the Israeli Ministry of Health withdrew licensing approval for troclosene sodium as a wound irrigation solution. The aim of this prospective clinical and laboratory study was to investigate the safety of troclosene sodium solution for decontamination of infected wounds. Troclosene sodium solution was used to treat 30 patients with 35 infected skin wounds of various etiologies and body areas, over a treatment period of 8 days. Data were gathered according to a prospectively designed protocol including general findings, wound‐specific observations on Day 1 and Day 8 and laboratory parameters on Day 1 and Day 8. Wound swabs and tissue biopsy for culture were taken on Day 1 and Day 8. Statistical analysis was executed. Tests were 2‐sided and p values of <0.05 were considered statistically significant. Eighteen males and 12 females, with 35 infected skin wounds were enrolled. There were no adverse clinical events. No significant changes were observed in general clinical observations. Statistically significant improvements were observed in: pain (p < 0.0001); edema (p < 0.0001); area of wound covered by granulation tissue (p < 0.0001); exudate (p < 0.0001); and erythema (p = 0.002). Prior to treatment, bacteria were demonstrated on microscopy or on culture in 90% of wound samples. On Day 8, this frequency reduced to 40%. There were no abnormal laboratory tests. Serum sodium concentration increased significantly between Day 1 and Day 8, whilst serum concentration of urea and concentrations of thrombocytes, leucocytes and neutrophils showed statistically significant reductions, but all values remained within normal laboratory ranges throughout the study period. Troclosene sodium solution is clinically safe in the management of infected wounds. These findings were presented to the Israel Ministry of Health and as a result, troclosene sodium was re‐approved and licensed for decontamination of infected wounds in Israel. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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