Gutted: constipation in children with chronic kidney disease and on dialysis.
Functional constipation is a common problem in otherwise healthy children. Children with chronic kidney disease (CKD) and on dialysis have additional disease-related risk factors including the uremic milieu, fluid and dietary restrictions, and decreased physical activity, as well as treatment-relate...
| Publicado en: | Pediatric Nephrology Vol. 38; no. 11; pp. 3581 - 3597 |
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| Autores principales: | , , , , , , |
| Formato: | exam questions pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172284994&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172284994 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Nov2023 vid: 38 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 172284994 161206199 172284994 172284994 10.1007/s00467-022-05849-y 172284994 ppf: 3581 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gutted: constipation in children with chronic kidney disease and on dialysis. aug: au: Wan, Mandy King, Lillian Baugh, Natasha Arslan, Zainab Snauwaert, Evelien Paglialonga, Fabio Shroff, Rukshana affil: Evelina Pharmacy Department, Evelina London Children's Hospital, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Road, SE1 7EH, London, UK sug: subj: Dialysis Patients In Infancy and Childhood Renal Insufficiency, Chronic Therapy Gut Microbiota Adverse Effects Constipation Epidemiology Child Pathologic Processes Risk Factors Constipation Therapy Cathartics Therapeutic Use Child: 6-12 years ab: Functional constipation is a common problem in otherwise healthy children. Children with chronic kidney disease (CKD) and on dialysis have additional disease-related risk factors including the uremic milieu, fluid and dietary restrictions, and decreased physical activity, as well as treatment-related risk factors such as dialysis therapy and polypharmacy that contribute to and compound the problem. Constipation causes significant distress for children and their caregivers. In children on peritoneal dialysis, severe constipation can impede catheter function and ultrafiltration. Accumulating evidence points to a possible bidirectional relationship between constipation and CKD, potentially mediated by gut dysbiosis with consequent increased generation of gut-derived uremic toxins and disruption of intestinal epithelium integrity leading to translocation of noxious luminal contents into the circulation inducing systemic inflammation. Effective management of constipation is required but there is little published data on the safety and effectiveness of treatments in adults or children with CKD. In this review, we discuss the diagnosis and epidemiology of functional constipation, provide an overview of its pathophysiology, summarize the therapeutic management, and reflect on the challenges in children with CKD. pubtype: Academic Journal doctype: exam questions pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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