Increasing SARS-CoV-2 seroprevalence among UK pediatric patients on dialysis and kidney transplantation between January 2020 and August 2021.
Background : Coronavirus disease 2019 (COVID-19) was officially declared a pandemic by the World Health Organisation (WHO) on 11 March 2020, as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly across the world. We investigated the seroprevalence of anti-SARS-CoV-2 antibodi...
| Publicado en: | Pediatric Nephrology Vol. 38; no. 11; pp. 3745 - 3756 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172285010&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172285010 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Nov2023 vid: 38 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 172285010 164030322 172285010 172285010 10.1007/s00467-023-05983-1 172285010 ppf: 3745 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Increasing SARS-CoV-2 seroprevalence among UK pediatric patients on dialysis and kidney transplantation between January 2020 and August 2021. aug: au: Bamber, Holly N. Kim, Jon Jin Reynolds, Ben C. Afzaal, Javairiya Lunn, Andrew J. Tighe, Patrick J. Irving, William L. Tarr, Alexander W. affil: https://ror.org/01ee9ar58 School of Life Sciences, University of Nottingham, Nottingham, UK sug: subj: COVID-19 United Kingdom Seroprevalence Studies Dialysis Patients In Infancy and Childhood Kidney Transplantation Transplant Recipients In Infancy and Childhood Peritoneal Dialysis Hemodialysis Human Male Female Child Adolescence United Kingdom Stay-at-Home Orders Social Distancing Renal Replacement Therapy Antibodies Cross Sectional Studies Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background : Coronavirus disease 2019 (COVID-19) was officially declared a pandemic by the World Health Organisation (WHO) on 11 March 2020, as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly across the world. We investigated the seroprevalence of anti-SARS-CoV-2 antibodies in pediatric patients on dialysis or kidney transplantation in the UK. Methods: Excess sera samples were obtained prospectively during outpatient visits or haemodialysis sessions and analysed using a custom immunoassay calibrated with population age-matched healthy controls. Two large pediatric centres contributed samples. Results: In total, 520 sera from 145 patients (16 peritoneal dialysis, 16 haemodialysis, 113 transplantation) were analysed cross-sectionally from January 2020 until August 2021. No anti-SARS-CoV-2 antibody positive samples were detected in 2020 when lockdown and enhanced social distancing measures were enacted. Thereafter, the proportion of positive samples increased from 5% (January 2021) to 32% (August 2021) following the emergence of the Alpha variant. Taking all patients, 32/145 (22%) were seropositive, including 8/32 (25%) with prior laboratory-confirmed SARS-CoV-2 infection and 12/32 (38%) post-vaccination (one of whom was also infected after vaccination). The remaining 13 (41%) seropositive patients had no known stimulus, representing subclinical cases. Antibody binding signals were comparable across patient ages and dialysis versus transplantation and highest against full-length spike protein versus spike subunit-1 and nucleocapsid protein. Conclusions: Anti-SARS-CoV-2 seroprevalence was low in 2020 and increased in early 2021. Serological surveillance complements nucleic acid detection and antigen testing to build a greater picture of the epidemiology of COVID-19 and is therefore important to guide public health responses. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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