A Randomized Clinical Trial to Evaluate a Digital Therapeutic to Enhance Gait Function in Individuals With Parkinson's Disease.
Background: Postural instability and gait dysfunction (PIGD) is a cardinal symptom of Parkinson's disease (PD) and is exacerbated under dual-task conditions. Dual-task training (DTT), enhances gait performance, however it is time and cost intensive. Digitizing DTT via the Dual-task Augmented Reality...
| Publicado en: | Neurorehabilitation & Neural Repair Vol. 37; no. 9; pp. 603 - 617 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Sage Publications Inc.
Sep2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172343209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172343209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459683 IRK jtl: Neurorehabilitation & Neural Repair issn: 15459683 maglogo: Y pubinfo: dt: Sep2023 vid: 37 iid: 9 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 172343209 165036019 172343209 172343209 10.1177/15459683231184190 172343209 ppf: 603 ppct: 14 formats: tig: atl: A Randomized Clinical Trial to Evaluate a Digital Therapeutic to Enhance Gait Function in Individuals With Parkinson's Disease. aug: au: Alberts, Jay L. Kaya, Ryan D. Penko, Amanda L. Streicher, Matthew Zimmerman, Eric M. Davidson, Sara Walter, Benjamin L. Rosenfeldt, Anson B. affil: Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA sug: subj: Parkinson Disease Therapy Digital Health Digital Technology Therapeutic Exercise Task Performance and Analysis Gait Disorders, Neurologic Balance, Postural Physiology Gait Physiology Human Male Randomized Controlled Trials Random Assignment Single-Blind Studies Descriptive Statistics Comparative Studies Functional Assessment Health Care Delivery Functional Status Funding Source Male ab: Background: Postural instability and gait dysfunction (PIGD) is a cardinal symptom of Parkinson's disease (PD) and is exacerbated under dual-task conditions. Dual-task training (DTT), enhances gait performance, however it is time and cost intensive. Digitizing DTT via the Dual-task Augmented Reality Treatment (DART) platform can expand the availability of an effective intervention to address PIGD. Objective: The aim of this project was to evaluate DART in the treatment of PIGD in people with PD compared to a Traditional DTT intervention. It was hypothesized that both groups would exhibit significant improvements in gait, and the improvements for the DART group would be non-inferior to Traditional DTT. Methods: A single-blind randomized controlled trial was conducted with 47 PD participants with PIGD. Both groups completed 16 therapeutic sessions over 8 weeks; the DART platform delivered DTT via the Microsoft HoloLens2. Primary outcomes included clinical ratings and single- and dual-task gait biomechanical outcomes. Results: Clinical measures of PD symptoms remained stable for DART and Traditional DTT groups. However, both groups exhibited a significant increase in gait velocity, cadence, and step length during single- and multiple dual-task conditions following the interventions. Improvements in gait velocity in the DART group were non-inferior to Traditional DTT under the majority of conditions. Conclusion: Non-inferior improvements in gait parameters across groups provides evidence of the DART platform being an effective digital therapeutic capable of improving PIGD. Effective digital delivery of DTT has the potential to increase use and accessibility to a promising, yet underutilized and difficult to administer, intervention for PIGD. Clinical Trial Registration: ClinicalTrials.gov Dual-task Augmented Reality Treatment for Parkinson's Disease (DART) NCT04634331; posted November 18, 2020. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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