The Seroprevalence of Hepatitis A in Patients with Positive Human Immunodeficiency Virus.
Background: Hepatitis A virus (HAV) can have severe manifestations in adult patients with other liver diseases, particularly in those infected with human immunodeficiency virus (HIV). This study aimed to measure immunity against HAV in HIV-positive individuals to determine the necessity of vaccinati...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 15; no. 3; pp. 196 - 203 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Jul2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172382708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172382708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Jul2023 vid: 15 iid: 3 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 172382708 172382708 172382708 10.34172/mejdd.2023.344 172382708 ppf: 196 ppct: 7 formats: fmt: @attributes: type: P tig: atl: The Seroprevalence of Hepatitis A in Patients with Positive Human Immunodeficiency Virus. aug: au: Omidifar, Navid Lankarani, Kamran Bagheri Ghadim, Mir Behrad Aghazadeh Khoshdel, Nika Joulaei, Hassan Keshani, Parisa Saghi, Seyyed Amirreza Nikmanesh, Yousef affil: Biotechnology Research Center and Department of Pathology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran sug: subj: HIV Infections HIV-Positive Persons Hepatitis A Immunology Hepatitis A Epidemiology Hepatitis A Vaccines Human Adolescence Adult Middle Age Aged Iran Cross Sectional Studies Seroprevalence Studies Immunoglobulins Antibodies, Viral Blood Descriptive Statistics Age Factors Hepatitis C Correlational Studies CD4 Lymphocyte Count Prevalence Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Background: Hepatitis A virus (HAV) can have severe manifestations in adult patients with other liver diseases, particularly in those infected with human immunodeficiency virus (HIV). This study aimed to measure immunity against HAV in HIV-positive individuals to determine the necessity of vaccination against HAV in this population. Methods: This cross-sectional study investigated 171 HIV-positive patients aged 18 years or older who were tested for serum IgG anti-viral hepatitis A antibody. The prevalence and its determinants were analyzed based on patient data. Results: The average age of the patients was 44.2 years old. The prevalence of HAV antibody positivity was 97.7%. The prevalence was higher in patients older than 30 years. There was a close association between hepatitis C virus (HCV) infection (P = 0.002). There were no significant correlations between antibody levels and sex, marital status, employment status, education level, economic status, smoking status, drug use status, and physical activity level. The mean and median CD4 + counts in patients with positive (reactive) antibody (Ab) levels were 458 and 404 ± 294, respectively, while the mean and median CD4 + counts in patients with non-reactive antibody levels were 806 and 737 ± 137, respectively, in those who tested negative for anti-HAV Ab (P = 0.05). Conclusion: The prevalence of anti-hepatitis A IgG antibodies in people with HIV was very high in Shiraz. There is an increasing trend in the number of older patients and those with HCV infections. The negative association with CD4 was borderline in this study, which needs to be confirmed in larger groups. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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