MxA for differentiating viral and bacterial infections in adults: a prospective, exploratory study.
Purpose: Inappropriate antibiotic prescription in patients with viral infections contributes to the surge of antibiotic resistance. Viral infections induce the expression of the antiviral protein MxA in monocytes, which is a promising biomarker to differentiate between viral and bacterial diseases....
| Publicado en: | Infection Vol. 51; no. 5; pp. 1329 - 1338 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172441948&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172441948 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Oct2023 vid: 51 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 172441948 161647698 172441948 172441948 10.1007/s15010-023-01986-0 172441948 ppf: 1329 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: MxA for differentiating viral and bacterial infections in adults: a prospective, exploratory study. aug: au: Metz, Matthäus Gualdoni, Guido A. Winkler, Heide-Maria Warenits, Alexandra-Maria Stöckl, Johannes Burgmann, Heinz Winkler, Stefan Oesterreicher, Zoe Anne affil: https://ror.org/05n3x4p02 Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, 1090, Vienna, Austria sug: subj: Bacterial Infections Diagnosis Coinfection Diagnosis Virus Diseases Diagnosis Carrier Proteins Metabolism Drug Resistance, Microbial Human Male Female Adolescence Adult Middle Age Aged Aged, 80 and Over Prospective Studies Exploratory Research Monocytes Flow Cytometry Immunosuppression Methods ROC Curve Sensitivity and Specificity Biological Markers One-Way Analysis of Variance Fisher's Exact Test Kruskal-Wallis Test Data Analysis Software Descriptive Statistics Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: Inappropriate antibiotic prescription in patients with viral infections contributes to the surge of antibiotic resistance. Viral infections induce the expression of the antiviral protein MxA in monocytes, which is a promising biomarker to differentiate between viral and bacterial diseases. In this prospective, exploratory study, we aimed to determine the diagnostic value of monocyte MxA expression in adults with viral, bacterial or co-infections. Methods: We measured monocyte MxA expression using flow cytometry in a cohort of 61 adults with various viral, bacterial and co-infections including patients receiving immunosuppressive therapy. Results: Monocyte MxA expression in virus-infected patients was significantly higher compared to bacterial infections (83.3 [66.8, 109.4] vs. 33.8 [29.3, 47.8] mean fluorescence intensity [MFI]; p < 0.0001) but not co-infections (53.1 [33.9, 88.9] MFI). At a threshold of 62.2 MFI, the area under the ROC curve (AUC) to differentiate between viral and bacterial infections was 0.9, with a sensitivity and specificity of 92.3% and 84.6%, respectively. Immunosuppressive therapy did not affect monocyte MxA expression in virus-infected patients. Conclusion: Our findings corroborate the diagnostic performance of MxA in differentiating viral and bacterial infections but also point to an important caveat of MxA in viral-bacterial co-infections. This study extends previous reports and indicates that MxA is also a useful biomarker in immunocompromised patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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