Effects of anodal tDCS on electroencephalography correlates of cognitive control in mild-to-moderate traumatic brain injury.
BACKGROUND: Transcranial direct current stimulation (tDCS) may provide a potential therapy for cognitive deficits caused by traumatic brain injury (TBI), yet its efficacy and mechanisms of action are still uncertain. OBJECTIVE: We hypothesized that anodal tDCS over the left dorsolateral prefrontal c...
| Publicado en: | NeuroRehabilitation Vol. 53; no. 2; pp. 209 - 221 |
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| Autores principales: | , , , , , , , , , |
| Formato: | clinical trial research tables/charts tracings Journal Article |
| Publicado: |
Sage Publications Inc.
2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172758130&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172758130 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2023 vid: 53 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 172758130 170048864 172758130 172758130 10.3233/NRE-230014 172758130 ppf: 209 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of anodal tDCS on electroencephalography correlates of cognitive control in mild-to-moderate traumatic brain injury. aug: au: Mertens, Nickolas Cavanagh, James Brandt, Emma Fratzke, Violet Story-Remer, Jacqueline Rieger, Rebecca Wilson, J. Kevin Gill, Darbi Campbell, Richard Quinn, Davin K. affil: Center for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA sug: subj: Transcranial Direct Current Stimulation Methods Electroencephalography Cognition Executive Function Brain Injuries Therapy Trauma Therapy Treatment Outcomes Human United States Clinical Trials Male Female Young Adult Adult Middle Age Pretest-Posttest Design Descriptive Statistics Neuronal Plasticity Dorsolateral Prefrontal Cortex Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Transcranial direct current stimulation (tDCS) may provide a potential therapy for cognitive deficits caused by traumatic brain injury (TBI), yet its efficacy and mechanisms of action are still uncertain. OBJECTIVE: We hypothesized that anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) would boost the influence of a cognitive training regimen in a mild-to-moderate TBI (mmTBI) sample. Cognitive enhancement was measured by examining event-related potentials (ERPs) during cognitive control tasks from pre- to post-treatment. METHODS: Thirty-four participants with mmTBI underwent ten sessions of cognitive training with active (n = 17) or sham (n = 17) anodal tDCS to the left DLPFC. ERPs were assessed during performance of an auditory oddball (3AOB), N-back, and dot pattern expectancy (DPX) task before and after treatment. RESULTS: P3b amplitudes significantly decreased from baseline to post-treatment testing, regardless of tDCS condition, in the N-back task. The active tDCS group demonstrated a significantly increased P3a amplitude in the DPX task. No statistically significant stimulation effects were seen during the 3AOB and N-back tasks. CONCLUSION: Active anodal tDCS paired with cognitive training led to increases in P3a amplitudes in the DPX, inferring increased cognitive control. P3b decreased in the N-back task demonstrating the effects of cognitive training. These dissociated P3 findings suggest separate mechanisms invoked by different neuroplasticity-inducing paradigms (stimulation versus training) in brain networks that support executive functioning. pubtype: Academic Journal doctype: clinical trial research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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