COVID-19 – a potential trigger for MOGAD-associated optic neuritis: a case report and literature review.
SARS-CoV-2 affects the nervous system directly by neurotoxic action, by binding to angiotensin-converting enzyme-2 (ACE2) receptors or indirectly by inducing cytokine storm leading to disruption of the blood-brain barrier, immunological mediation, increasing blood coagulation and as a trigger for au...
| Publicado en: | Therapeutic Advances in Ophthalmology pp. 1 - 10 |
|---|---|
| Autores principales: | , , , |
| Formato: | case study diagnostic images pictorial tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
10/6/2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172849933&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172849933 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25158414 LAW0 jtl: Therapeutic Advances in Ophthalmology issn: 25158414 maglogo: Y pubinfo: dt: 10/6/2023 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 172849933 172849933 172849933 10.1177/25158414231199541 172849933 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: COVID-19 – a potential trigger for MOGAD-associated optic neuritis: a case report and literature review. aug: au: Bhardwaj, Ankit Mishra, Hara Prasad Goel, Ayush Gupta, Ashi affil: Conceptualization, Department of Pharmacology, UCMS & GTB Hospital, Dilshad Garden, Delhi 110095, India sug: subj: Optic Neuritis Risk Factors COVID-19 Complications Central Nervous System Diseases Risk Factors Optic Neuritis Diagnosis Optic Neuritis Drug Therapy Methylprednisolone Therapeutic Use Immunoglobulins Administration and Dosage Administration, Intravenous Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Complications Adult Female Hematologic Tests Electrolytes Immunoglobulins Blood Electrophoresis Antibodies Blood Contrast Media Diagnostic Use Magnetic Resonance Imaging Brain Pathology Patient Discharge Treatment Outcomes Adult: 19-44 years Female ab: SARS-CoV-2 affects the nervous system directly by neurotoxic action, by binding to angiotensin-converting enzyme-2 (ACE2) receptors or indirectly by inducing cytokine storm leading to disruption of the blood-brain barrier, immunological mediation, increasing blood coagulation and as a trigger for autoimmune-mediated demyelinating injuries in the central nervous system. In COVID-19 neuro-ophthalmological manifestations are not so common. Optic neuritis is the result of optic nerve inflammation and has varied causes. In many patients, signs of inflammation are not visible on the fundus, and it usually manifests as papillitis-anterior neuritis, retrobulbar neuritis or visible optic nerve oedema. We are reporting a case of a middle-aged adult diagnosed with myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis of the right eye post-COVID-19 disease. Routine biochemical and haematological investigations, including electrolytes and hepatic and renal functions, were normal. In cerebrospinal fluid (CSF) – glucose 63.8 mg/dL, protein 39.1 mg/dL and ADA – 1 µ/L. No oligoclonal bands of immunoglobulin G (IgG) were seen on high-resolution electrophoresis. Serum Anti-MOG-antibodies were positive. A gadolinium-contrast magnetic resonance imaging (MRI) of the brain and orbits shows post-contrast enhancement in the superior aspect of the right intraconal soft tissue. The right optic nerve appears bulky and heterogeneous with peripheral post-contrast enhancement along its entire length suggestive of neuritis. A diagnosis of MOG antibody-positive optic neuritis was made, and the patient was treated with an injection of Methylprednisolone with intravenous immunoglobulin. Each day, the evaluation of the right eye showed remarkable improvement from finger counting to 6/6 vision. The patient was discharged on the 9th day of admission. We can conclude that early diagnosis was essential for improving the long-term outcome of the patient. pubtype: Academic Journal doctype: case study diagnostic images pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|