Evaluation of individual-based morphological brain network alterations in children with attention-deficit/hyperactivity disorder: a multi-method investigation.
To investigate the topological organization of individual-based morphological brain networks (MBNs) in attention-deficit/hyperactivity disorder (ADHD) children with different methods. A total of 60 ADHD children and 60 typically developing (TD) controls matched for age and gender were enrolled. Each...
| Published in: | European Child & Adolescent Psychiatry Vol. 32; no. 11; pp. 2281 - 2290 |
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| Main Authors: | , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Nov2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=172970479&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 172970479 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Nov2023 vid: 32 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 172970479 158841398 172970479 172970479 10.1007/s00787-022-02072-w 172970479 ppf: 2281 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evaluation of individual-based morphological brain network alterations in children with attention-deficit/hyperactivity disorder: a multi-method investigation. aug: au: Su, Shu Chen, Yingqian Qian, Long Dai, Yan Yan, Zi Lin, Liping Zhang, Hongyu Liu, Meina Zhao, Jing Yang, Zhiyun affil: https://ror.org/037p24858 Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China sug: subj: Brain Pathology Brain Anatomy and Histology Attention Deficit Hyperactivity Disorder In Infancy and Childhood Brain Mapping Human Children with Disabilities Multimethod Studies Child Neural Pathways Case Control Studies Male Female Age Factors Sex Factors Correlational Studies Severity of Illness Magnetic Resonance Imaging Child: 6-12 years Male Female ab: To investigate the topological organization of individual-based morphological brain networks (MBNs) in attention-deficit/hyperactivity disorder (ADHD) children with different methods. A total of 60 ADHD children and 60 typically developing (TD) controls matched for age and gender were enrolled. Each participant underwent a structural 3D T1-weighted scan. Based on the inter-regional morphological similarity of GM regions, Kullback–Leibler-based similarity (KLS), Multivariate Euclidean Distance (MED), and Tijms's method were used to construct individual-based MBNs, respectively. The between-group difference of global and nodal network topological profiles was estimated, and partial correlation analysis was used for further analysis. According to KLS and MED-based network, ADHD showed a decreased global efficiency (Eglob) and increased characteristic path length (Lp) compared to the TD group, while Tijms's method-based network showed no between-group difference in global and nodal profiles. Nodal profiles were significantly decreased in the bilateral caudate, and nodal efficiency of the bilateral caudate was negatively correlated with clinical symptom severity of ADHD (P < 0.05, FDR-corrected) by the KLS-based network. Nodal betweenness was significantly decreased in the left inferior occipital gyrus and correlated with clinical symptom severity of ADHD (P < 0.05, FDR-corrected) by the MED-based network. ADHD was found to have a significantly less integrated organization and a shift to a "weaker small-worldness" pattern, while abnormal nodal profiles were mainly in the corpus striatum and default-mode networks. Our study highlights the crucial role of abnormal morphological connectivity patterns in understanding the brain maturational effects in ADHD and enriching the insights into MBNs at an individual level. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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