Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial.
Background: This trial aimed to evaluate the anti-obesity effects and safety of Neoagaro-oligosaccharides (NAOs) in humans in a 16 week, randomized, double-blind, placebo-controlled clinical trial. Methods: One hundred overweight or obese subjects with a body mass index of 23 to 34.9 kg/m2 and a per...
| Published in: | BMC Complementary Medicine & Therapies Vol. 23; no. 1; pp. 1 - 14 |
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| Main Authors: | , , , , , , |
| Format: | diagnostic images research tables/charts randomized controlled trial Journal Article |
| Published: |
BioMed Central
10/19/2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173150512&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173150512 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26627671 MFH8 jtl: BMC Complementary Medicine & Therapies issn: 26627671 maglogo: N pubinfo: dt: 10/19/2023 vid: 23 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 173150512 173150512 173150512 10.1186/s12906-023-04206-2 173150512 ppf: 1 ppct: 13 formats: tig: atl: Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial. aug: au: Baek, Hyang-Im Ha, Ki-Chan Park, Yu Kyung Lee, Je Hyeon Kim, Eun Joo Ko, Hye-Jeong Joo, Jong Cheon affil: https://ror.org/00emz0366 Department of Food Science & Nutrition, Woosuk University, 55338, Wanju, Republic of Korea sug: subj: Antiobesity Agents Therapeutic Use Obesity Drug Effects Obesity Drug Therapy Obesity Prevention and Control Placebos Therapeutic Use Human Male Female Patient Safety Randomized Controlled Trials Placebos Administration and Dosage Biological Markers Body Mass Index Lipoproteins, HDL Double-Blind Studies Random Assignment Food Intake Physical Activity Descriptive Statistics Chi Square Test T-Tests Funding Source Male Female ab: Background: This trial aimed to evaluate the anti-obesity effects and safety of Neoagaro-oligosaccharides (NAOs) in humans in a 16 week, randomized, double-blind, placebo-controlled clinical trial. Methods: One hundred overweight or obese subjects with a body mass index of 23 to 34.9 kg/m2 and a percent body fat of > 25% for males or > 30% for females were enrolled. NAOs or placebo products were administered at 3 g (twice a day, four capsules once) each for 16 weeks. Efficacy and safety biomarkers were measured before and after intervention. Results: After 16 weeks of intervention, the group administered with NAOs had statistically significant decreases in visceral fat area and visceral-subcutaneous fat area ratio compared to the placebo group. The NAOs group suppressed the increase in weight and BMI compared to the placebo group, which was significant between groups. High-density lipoprotein- cholesterol was increased in the group administered with NAOs, which showed a significant trend compared to the placebo group. Clinical changes were not observed for any safety biomarkers. Conclusions: These results suggest that NAOs have a beneficial effect on obesity. Thus, NAOs could be used as an anti-obesity supplement without side effects. Trial registration: cris.nih.go.kr: (KCT0006640, 07/10/2021). pubtype: Academic Journal doctype: diagnostic images research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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