Neuropsychological Correlates of Adherence in Youth with Behaviorally Acquired HIV.
Youth living with behaviorally acquired HIV (YLWH) are at-risk for both neuropsychological disorders and antiretroviral therapy (ART) non-adherence; little is known about their interrelationship over time in YLWH. Neuropsychological and psychiatric functioning, substance use, and self-report of 7-da...
| Publicado en: | AIDS & Behavior Vol. 27; no. 11; pp. 3813 - 3830 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173150955&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173150955 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10907165 G1T jtl: AIDS & Behavior issn: 10907165 maglogo: N pubinfo: dt: Nov2023 vid: 27 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 173150955 164457665 173150955 173150955 10.1007/s10461-023-04096-y 173150955 ppf: 3813 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neuropsychological Correlates of Adherence in Youth with Behaviorally Acquired HIV. aug: au: Garvie, Patricia A. Loop, Matthew S. Zhou, Christina W. McCumber, Micah Woods, Steven Paul Nichols, Sharon L. affil: https://ror.org/03pab6q64 Research Department, Children's Diagnostic & Treatment Center, Fort Lauderdale, FL, USA sug: subj: HIV-Positive Persons In Adolescence HIV Infections Drug Therapy Anti-HIV Agents Therapeutic Use Neuropsychology Patient Compliance Funding Source Human Female Male Adolescence Young Adult Prospective Studies Self Report Odds Ratio Motor Skills Executive Function Adolescent: 13-18 years Female Male ab: Youth living with behaviorally acquired HIV (YLWH) are at-risk for both neuropsychological disorders and antiretroviral therapy (ART) non-adherence; little is known about their interrelationship over time in YLWH. Neuropsychological and psychiatric functioning, substance use, and self-report of 7-day/week and weekend ART adherence were assessed at baseline and Weeks 24, 48, 96 and 144 of a longitudinal study evaluating the impact of early (CD4>350) versus standard of care (CD4≤350) treatment initiation on neuropsychological functioning in 111 treatment-naïve YLWH age 18–24 years at entry. Bayesian multi-level models for adherence (≥ 90% vs. <90%) were fit using random intercepts for repeated measures. Adjusted odds ratios (OR [95% credible interval]) for higher versus lower baseline Motor function for visit adherence were 0.58 (0.25, 1.16), 0.5 (0.15, 1.38), 0.52 (0.16, 1.52), and 0.94 (0.3, 2.8) at Weeks 24, 48, 96, and 144, respectively. Week 24 adherence was associated with higher adjusted odds of Motor function at Week 48 (week: 0.27, -0.05–0.59; weekend: 0.28, -0.07–0.62). Week 96 Complex Executive functioning was associated with higher adjusted odds of adherence at Week 144, OR = 4.26 (1.50, 14.33). Higher Motor functioning emerged most consistently associated with lower odds of adherence in YLWH. Complex Executive functioning was associated with adherence only at end of study, suggesting potential contribution in adherence over the long-term. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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