Comparison of Carcinoembryonic Antigen Level and E-Cadherin Expression between Metastatic and Non-Metastatic Colorectal Carcinoma in RSUP, Dr. Sardjito Yogyakarta-Indonesia.
Background: WHO has reported 34,189 (8.6%) colorectal carcinoma cases out of 396,914 total cancer cases in Indonesia. Accumulated gene mutation and the environment can affect cell regulation, growth, and differentiation, impacting the methylation of tumor suppressor genes. Carcinoembryonic antigen (...
| Publicado en: | Middle East Journal of Cancer Vol. 14; no. 4; pp. 521 - 530 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Middle East Journal of Cancer
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173385915&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173385915 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20086709 B7LE jtl: Middle East Journal of Cancer issn: 20086709 maglogo: N pubinfo: dt: Oct2023 vid: 14 iid: 4 pid: 67247 pub: Middle East Journal of Cancer artinfo: ui: 173385915 173385915 173385915 10.30476/mejc.2023.94695.1737 173385915 ppf: 521 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Comparison of Carcinoembryonic Antigen Level and E-Cadherin Expression between Metastatic and Non-Metastatic Colorectal Carcinoma in RSUP, Dr. Sardjito Yogyakarta-Indonesia. aug: au: Prabowo, Rianto Susanto, Hendra Setiawan, Nurcahya Sofii, Imam Barmawi, Agus Handaya, Adeodatus Yuda affil: Digestive Surgery Division, Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia sug: subj: Antigens, Tumor Pharmacodynamics Antigens, Tumor Blood Gene Expression Neoplasm Metastasis Diagnosis Colorectal Neoplasms Diagnosis Colorectal Neoplasms Drug Therapy Human Male Female Comparative Studies Indonesia World Health Organization Descriptive Statistics Mutation Methylation Genes, Tumor Suppressor Homeostasis Analysis of Variance T-Tests Pearson's Correlation Coefficient Reverse Transcriptase Polymerase Chain Reaction Aminotransferases Male Female ab: Background: WHO has reported 34,189 (8.6%) colorectal carcinoma cases out of 396,914 total cancer cases in Indonesia. Accumulated gene mutation and the environment can affect cell regulation, growth, and differentiation, impacting the methylation of tumor suppressor genes. Carcinoembryonic antigen (CEA) is a biomarker used to detect the presence of colorectal carcinoma. Moreover, the E-cadherin gene has an essential role in tissue homeostasis, the adhesion between cells at embryogenesis, tissue morphogenesis, differentiation, and carcinogenesis stages. During instability and dysfunction in its regulation, the E-cadherin gene induces tumor progression. This study aimed to compare the level of CEA and E-cadherin expression in metastatic and non-metastatic sample groups. Method: The present study is descriptive with a quantitative approach using ANOVA one-way, unpaired t-test, and Pearson correlation analysis for the measurement and comparison of the CEA level and relative gene expression value from the reverse transcription-quantitative polymerase chain reaction analysis. Results: The obtained results suggested increasing CEA level and decreasing Ecadherin expression on the metastatic sample. Statistically, E-cadherin proven to show a negative r value or correlation value of CEA, even though it has a significant P-value. In other parameters, alanine transaminase and aspartate aminotransferase indicated a positive r value and a significant P-value. Conclusion: These findings indicated the potential clinical benefit of E-cadherin in detecting tumor progressivity, supported by other significant parameters, such as alanine transaminase and aspartate aminotransferase. Furthermore, E-cadherin was found beneficial in diagnosing the colorectal carcinoma with liver metastatis. Nonetheless, further research is needed to determine the role of E-cadherin regulation in colorectal cancer metastatis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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