Evaluation of TRAF3IP2 Gene Expression in Brain Tumor Tissue of Patients with Glioblastoma Multiforme in Comparison to Non-Tumoral Brain Tissue.
Background: Glioblastoma, not otherwise specified (NOS), is the most common primary malignant brain tumor. The TRAF3IP2 gene is an upstream regulator responsible for activating multiple proinflammatory pathways that could influence tumor size, angiogenesis, aggressiveness, and metastasis. In the pre...
| Publicado en: | Middle East Journal of Cancer Vol. 14; no. 4; pp. 543 - 550 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
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Middle East Journal of Cancer
Oct2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173385918&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173385918 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20086709 B7LE jtl: Middle East Journal of Cancer issn: 20086709 maglogo: N pubinfo: dt: Oct2023 vid: 14 iid: 4 pid: 67247 pub: Middle East Journal of Cancer artinfo: ui: 173385918 173385918 173385918 10.30476/mejc.2023.96063.1800 173385918 ppf: 543 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Evaluation of TRAF3IP2 Gene Expression in Brain Tumor Tissue of Patients with Glioblastoma Multiforme in Comparison to Non-Tumoral Brain Tissue. aug: au: Mahzouni, Parvin Seddighin, Roya Ghasroldasht, Mohammad Mousaei affil: Department of Pathology, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran sug: subj: Glioma Physiopathology Gene Expression Evaluation Tissue Analysis Human Male Female Cancer Patients Funding Source Comparative Studies Case Control Studies Biopsy RNA Polymerase Chain Reaction Methods Descriptive Statistics Sex Factors Male Female ab: Background: Glioblastoma, not otherwise specified (NOS), is the most common primary malignant brain tumor. The TRAF3IP2 gene is an upstream regulator responsible for activating multiple proinflammatory pathways that could influence tumor size, angiogenesis, aggressiveness, and metastasis. In the present study, we aimed to investigate and assess the TRAF3IP2 gene expression in brain tumor tissue of patients with glioblastoma, NOS and compare it with non-neoplastic brain tissue. Method: In this case-control study, biopsies were obtained from 15 surgically glioblastoma, NOS removed block samples and 15 non-neoplastic brain tissue samples containing normal white and gray matter as controls. Ribonucleic acid (RNA) was isolated and reverse-transcribed to complementary DNA (cDNA). Quantitative polymerase chain reaction (qPCR) was then carried out to measure TRAF3IP2 gene expression. Results: We evaluated data from 30 cases, divided into two groups: case (N = 15) and control (N = 15). Based on our data, the expression of the TRAF3IP2 gene was 6.95 ± 0.65 times higher in glioblastoma multiforme tissue compared with controls (P < 0.05). We also found no significant difference in TRAF3IP2 gene expression between genders (P = 0.452), and there was no significant correlation between TRAF3IP2 gene expression and age (P = 0.745). Conclusion: The expression of the TRAF3IP2 gene was almost seven times higher in glioblastoma, NOS brain tissue compared with normal brain samples. This finding could have significant clinical and therapeutic implications. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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