Neurophysiological error processing and addiction self‐awareness correlates of reduced insight in cannabis use disorder.
Background and Aims: Cannabis use disorder (CUD) prevalence has increased, while perceived risks of cannabis use and CUD treatment need have decreased. Chronic cannabis use may also impair the neural and behavioral mechanisms of insight, further hampering treatment‐seeking. This study aimed to measu...
| Publicado en: | Addiction Vol. 118; no. 12; pp. 2397 - 2413 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173396934&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173396934 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Dec2023 vid: 118 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 173396934 170072854 173396934 173396934 10.1111/add.16321 173396934 ppf: 2397 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Neurophysiological error processing and addiction self‐awareness correlates of reduced insight in cannabis use disorder. aug: au: Macatee, Richard J. Schermitzler, Brandon S. Minieri, Jessica B. Moeller, Scott J. Afshar, Kaveh Preston, Thomas J. affil: Department of Psychological Sciences, Auburn University, Auburn Alabama,, USA sug: subj: Cannabis Substance Use Disorders Substance Dependence Cognition Disorders Human Alabama Female Male Case Control Studies Task Performance and Analysis Recognition (Psychology) Electroencephalography Motivation Sociodemographic Factors Fisher's Exact Test Odds Ratio Confidence Intervals Descriptive Statistics Female Male ab: Background and Aims: Cannabis use disorder (CUD) prevalence has increased, while perceived risks of cannabis use and CUD treatment need have decreased. Chronic cannabis use may also impair the neural and behavioral mechanisms of insight, further hampering treatment‐seeking. This study aimed to measure whether CUD is characterized by reduced self‐monitoring in drug‐related contexts (objectively‐assessed insight), subserved by functional neural abnormalities in error‐processing and manifested clinically as decreased awareness of the need to change. Design: Case–control laboratory study was used. Setting: University setting was in Alabama, USA. Participants: There were 42 CUD participants and 47 age‐, sex‐, and nicotine use‐matched controls. Measurements: Participants completed a probabilistic choice task, adapted for the first time for CUD, in which they selected pleasant, unpleasant, neutral, and cannabis‐related images according to their preference. Reduced versus accurate insight was operationalized as the correspondence between self‐reported and actual most chosen image type. Neurophysiological error‐processing during an inhibitory control task was recorded using electroencephalography. Participants with CUD completed measures of cannabis problem recognition and motivation to change. Findings Compared with controls, the CUD group made significantly more cannabis selections on the choice task (mean difference [MD] = 8.11, 95% confidence interval [CI] [4.88 11.35], p < 0.001) and had significantly reduced insight into cannabis choice (odds ratio [OR] = 9.69, 95% CI [1.06 88.65], p = 0.04). CUD participants with reduced insight on the choice task had significantly decreased neurophysiological reactivity to errors on the inhibitory control task (error‐related negativity) compared with CUD participants with accurate insight (MD = 2.64 μV, 95% CI [0.74 μV 4.54 μV], p = 0.008) and controls (MD = 4.05 μV, 95% CI [1.29 μV 6.80 μV], p = 0.005). Compared with CUD participants with accurate insight on the choice task, CUD participants with reduced insight reported significantly less agreement that they had a cannabis problem (MD = ‐5.06, 95% CI [−8.49–1.62], p = 0.003). Conclusions: People with CUD who show reduced insight on a drug‐related choice task may also have decreased early neural error‐processing and less cannabis problem recognition. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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