Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.

Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses...

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Publicado en:Journal of Autism & Developmental Disorders Vol. 53; no. 12; pp. 4856 - 4872
Autores principales: Haigh, Sarah M., Van Key, Laura, Brosseau, Pat, Eack, Shaun M., Leitman, David I., Salisbury, Dean F., Behrmann, Marlene
Formato: research tables/charts tracings Journal Article
Publicado: Springer Nature Dec2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2023
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      pub: Springer Nature
      place: New York, New York
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        atl: Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.
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        au:
          Haigh, Sarah M.
          Van Key, Laura
          Brosseau, Pat
          Eack, Shaun M.
          Leitman, David I.
          Salisbury, Dean F.
          Behrmann, Marlene
        affil: https://ror.org/01keh0577 Department of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Reno, NV, USA
      sug:
        subj:
          Autism Spectrum Disorder Physiopathology
          Schizophrenia Physiopathology
          Neural Pathways Physiopathology
          Brain Physiopathology
          Acoustic Stimulation
          Evoked Potentials, Auditory
          Human
          Comparative Studies
          Psychiatric Patients
          Evoked Potentials, Somatosensory
          Sound
          Auditory Perception
          Descriptive Statistics
          Adult
          Female
          Male
          Funding Source
          Adult: 19-44 years
          Female
          Male
      ab: Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
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      ougenre: Article
    language: English
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