Nonhealing Leg Ulcer as the Presentation of Sarcoidosis: A Case Report.

Chronic leg ulcers (CLUs) are common, with increasing prevalence in the elderly population. Circulatory dysfunctions are responsible for 90% to 95% of all causes, while 5% to 10% of CLUs are associated with underlying chronic systemic disorders. Sarcoidosis is a complex multisystemic disease charact...

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Publicado en:International Journal of Lower Extremity Wounds Vol. 22; no. 4; pp. 742 - 748
Autores principales: Shatnawi, Nawaf J., Al-Zoubi, Nabil A., Al-Bakkar, Lujain A., Gharaibeh, Laith M., Hamouri, Shadi
Formato: case study diagnostic images pictorial Journal Article
Publicado: Sage Publications Inc. Dec2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2023
      vid: 22
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      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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      tig:
        atl: Nonhealing Leg Ulcer as the Presentation of Sarcoidosis: A Case Report.
      aug:
        au:
          Shatnawi, Nawaf J.
          Al-Zoubi, Nabil A.
          Al-Bakkar, Lujain A.
          Gharaibeh, Laith M.
          Hamouri, Shadi
        affil: 37251 Jordan University of Science and Technology, Irbid, Jordan
      sug:
        subj:
          Sarcoidosis Symptoms
          Sarcoidosis Diagnosis
          Female
          Adult
          Leg Ulcer Epidemiology
          Biopsy
          Granuloma Diagnosis
          Pyoderma Diagnosis
          Lymph Nodes Surgery
          Wound Healing
          Wound Care
          Negative Pressure Wound Therapy
          Skin Transplantation Methods
          Leg Ulcer Therapy
          Adult: 19-44 years
          Female
      ab: Chronic leg ulcers (CLUs) are common, with increasing prevalence in the elderly population. Circulatory dysfunctions are responsible for 90% to 95% of all causes, while 5% to 10% of CLUs are associated with underlying chronic systemic disorders. Sarcoidosis is a complex multisystemic disease characterized by noncaseating granulomas affecting mainly the pulmonary system, with cutaneous manifestation in 25% to 30% of cases. However, ulcerative sarcoidosis (US) is a rare form of cutaneous sarcoidosis. Pyoderma gangrenosum (PG) is an uncommon, chronic inflammatory noninfectious skin disease affecting different body parts. The ulcerative form of PG is rarely reported in association with sarcoidosis. We aim to report a 44-year-old female patient with a history of hypertension and varicose veins, presenting with a CLU for more than 18 months. Ulcer tissue biopsy showed noncaseating granuloma with abscess formation suggestive of sarcoidosis; however, PG could not be ruled out. Mediastinal lymph node biopsy was consistent with sarcoidosis. The leg ulcer had complete healing within 4 months by local wound management, negative pressure wound therapy, and split-thickness skin grafting without immunosuppressive treatment to achieve wound healing.
      pubtype: Academic Journal
      doctype:
        case study
        diagnostic images
        pictorial
        Journal Article
      ougenre: Article
    language: English
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