Circulating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia.
Individuals with X-linked hypophosphatemia (XLH) are at greater risk for being overweight or obese. Whether there are underlying metabolic abnormalities that put patients with XLH at greater risk for excessive weight gain is largely unknown. Lipocalin-2 (LCN2) has recently received attention as a fa...
| Publicado en: | Journal of the Endocrine Society Vol. 7; no. 11; pp. 1 - 5 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173472177&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173472177 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 24721972 LBOG jtl: Journal of the Endocrine Society issn: 24721972 maglogo: N pubinfo: dt: Nov2023 vid: 7 iid: 11 pid: 622 pub: Oxford University Press / USA artinfo: ui: 173472177 10.1210/jendso/bvad116 173472177 ppf: 1 ppct: 4 formats: tig: atl: Circulating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia. aug: au: Simpson, Christine A Santoro, Anna Maria Carpenter, Thomas O Deng, Yanhong Parziale, Stephen Insogna, Karl L affil: Department of Internal Medicine, Yale University , New Haven, CT 06510 , USA sug: ab: Individuals with X-linked hypophosphatemia (XLH) are at greater risk for being overweight or obese. Whether there are underlying metabolic abnormalities that put patients with XLH at greater risk for excessive weight gain is largely unknown. Lipocalin-2 (LCN2) has recently received attention as a factor regulating energy consumption and specifically is postulated to be anorexigenic and to improve insulin sensitivity. In a retrospective study, circulating levels of LCN2, leptin, and insulin were measured in 32 patients with XLH, ages 2-60 years, all of whom were being treated with burosumab, and 38 control subjects. Control subjects were chosen who were close in age to those with XLH, with a similar number of participants of each sex. Subjects were analyzed in 3 age cohorts, 2-10 years, 11-18 years, and 20-60 years. In all age groups LCN2 levels were lower in the patients with XLH than in controls but when adjusted for weight class (normal, overweight, obese) the differences were not significant. In contrast, serum leptin levels were significantly lower in children with XLH compared to controls in the 2-10 years age cohort. Serum levels of insulin were also significantly lower in the 2-10-year-old children with XLH when compared with controls. We conclude that changes in expression of lipocalin-2 in children and adolescents with XLH is unlikely to contribute to their risk for obesity in adulthood. It is unclear if lower circulating levels of leptin in these children plays a role in the higher prevalence of obesity among adults with XLH. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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