The study of bioavailability and endogenous circadian rhythm of menaquinone-7, a form of vitamin K2, in healthy subjects.
Menaquinone-7 (MK-7), a multipotent vitamin K2, possesses a wide range of biological activities, a precise curative effect and excellent safety. A simple and rapid LC-APCI-MS/MS method for the determination of MK-7 in human plasma with single liquid–liquid extraction (LLE) extraction and 4·5-min ana...
| Publicado en: | British Journal of Nutrition Vol. 130; no. 11; pp. 1885 - 1898 |
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| Autores principales: | , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
12/14/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173476440&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173476440 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00071145 1XX jtl: British Journal of Nutrition issn: 00071145 maglogo: N pubinfo: dt: 12/14/2023 vid: 130 iid: 11 pid: 15979 pub: Cambridge University Press artinfo: ui: 173476440 173476440 173476440 10.1017/S0007114523001034 173476440 ppf: 1885 ppct: 13 formats: tig: atl: The study of bioavailability and endogenous circadian rhythm of menaquinone-7, a form of vitamin K2, in healthy subjects. aug: au: Du, Fan Yan, Min Duan, Lili Xie, Guolong Yao, Xiuhua Hu, Wenjing Liu, Yu Meng, Min Chen, Jiepeng Shao, Di affil: Chonggang General Hospital, Chongqing, People's Republic of China sug: subj: Vitamin K Pharmacokinetics Biological Availability Circadian Rhythm Human Albumins Male Vitamin K Administration and Dosage Pilot Studies Funding Source Male ab: Menaquinone-7 (MK-7), a multipotent vitamin K2, possesses a wide range of biological activities, a precise curative effect and excellent safety. A simple and rapid LC-APCI-MS/MS method for the determination of MK-7 in human plasma with single liquid–liquid extraction (LLE) extraction and 4·5-min analysis time has been developed and validated. Four per cent bovine serum albumin (BSA) was used as surrogate matrix for standard curves and endogenous baseline subtraction. This method was reproducible and reliable and was used to analyse of MK-7 in human plasma. The endogenous circadian rhythm and bioavailability of MK-7 were investigated in two randomised single-dose, open, one-way clinical trials (Study I and Study II). A total of five healthy male subjects were enrolled in Study I and 12 healthy male subjects in Study II. Single-dose (1 mg) of MK-7 was given to each subject under fasting condition, and all eligible subjects were given a restricting VK2 diet for 4 d prior to drug administration and during the trial. The experiment results of Study I demonstrated that endogenous MK-7 has no circadian rhythm in individuals. Both studies showed MK-7 are absorbed with peak plasma concentrations at about 6 h after intake and has a very long half-life time. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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