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Intracranial hemorrhage outcomes in the Latin American Stroke Registry.

Background: Intracranial hemorrhage (ICH) carries a significant morbidity and mortality burden; however, there is scarce information in Latin American. Objective: To analyze the functional prognosis and mortality rates among participants in the Latin American Stroke Registry (LASE). Methods: Eightee...

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Published in:Revista Mexicana de Neurociencia Vol. 24; no. 6; pp. 185 - 192
Main Authors: Serrano, Fabiola, Barboza, Miguel A., Ameriso, Sebastian F., Pujol-Lereis, Virginia, Flores, Alan, Bayona, Hernán, Fernández, Huberth, Castillo, Alejandro, Ecos, Rosa, Vazquez, Jorge, Amaya, Pablo, Ruiz, Angélica, López, Minerva, Zapata, Carlos, Roa, Luis, Marquez-Romero, Juan M., Ochoa, Marco A., Morelos, Eugenia, León, Carolina, Romero, Felipe
Format: Article
Published: Academia Mexicana de Neurologia Nov/Dec2023
Subjects:
Intracranial hemorrhage
Stroke patients
Demographic surveys
Prognosis
Latin America
Online Access:View this record in EBSCOhost
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      dt: Nov/Dec2023
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        atl: Intracranial hemorrhage outcomes in the Latin American Stroke Registry.
      aug:
        au:
          Serrano, Fabiola
          Barboza, Miguel A.
          Ameriso, Sebastian F.
          Pujol-Lereis, Virginia
          Flores, Alan
          Bayona, Hernán
          Fernández, Huberth
          Castillo, Alejandro
          Ecos, Rosa
          Vazquez, Jorge
          Amaya, Pablo
          Ruiz, Angélica
          López, Minerva
          Zapata, Carlos
          Roa, Luis
          Marquez-Romero, Juan M.
          Ochoa, Marco A.
          Morelos, Eugenia
          León, Carolina
          Romero, Felipe
        affil: Latin American Stroke Registry, Mexico City, Mexico
      su:
        Intracranial hemorrhage
        Stroke patients
        Demographic surveys
        Prognosis
        Latin America
      sug:
        subj:
          Latin America
          Intracranial hemorrhage
          Stroke patients
          Demographic surveys
          Prognosis
      keyword:
        Hemorragia Intracraneal
        Latinoamérica
        Registro de Enfermedad Vascular Cerebral
        Resultado de la enfermedad vascular cerebral
        Stroke outcome
        Stroke registry
        Hemorragia Intracraneal
        Latinoamérica
        Registro de Enfermedad Vascular Cerebral
        Resultado de la enfermedad vascular cerebral
      ab:
        Background: Intracranial hemorrhage (ICH) carries a significant morbidity and mortality burden; however, there is scarce information in Latin American. Objective: To analyze the functional prognosis and mortality rates among participants in the Latin American Stroke Registry (LASE). Methods: Eighteen centers across Latin American compiled data on demographics, vascular risk factors, clinical stroke description, ancillary tests, and functional outcomes in hospital stay of patients included from January 2012 to January 2017. All these variables were analyzed based on functional outcome at hospital discharge. Results: We included 495 patients with ICH, representing 10.3% of all collected stroke subtypes in LASE. The median in-hospital stay was 9 days (interquartile range, 1-30); 285 (57.6%) were male (median age, 62 years) and 210 female (median age, 65 years). A poor functional outcome (modified Rankin scale, 3-6) was observed in 214 (43.2%) patients, with 62.5% of women (p < 0.009). Mortality was documented in 12.5% of ICH patients. The Kaplan-Meier survival curves presented difference in mortality, with higher frequency in patients > 80 years (HR 1.89,95%C1 1.07-3.35, p = 0.028), with GCS < 8 (HR 0.19, 95%CI 0.11-0.33, p = < 0.001), ventricular irruption (HR 1.88, 95%CI 1.09-3.24, p = 0.0282), and hematoma volume > 30 cc (HR 2.36, 95%C11.17 - 4.77, p = 0.016). Conclusions: Our study demonstrates a poor functional prognosis in 43.2% of ICH patients, with the risk factors for higher mortality being age over 80 years, higher GCS values, and ventricular irruption in the LASE. Our collaborative study contributes substantial insight into the factors influencing ICH occurrence, prognosis, and outcomes in Latin America.
        Introducción: La Hemorragia Intracraneal (ICH) conlleva una importante carga de morbilidad y mortalidad; sin embargo, existe escasa información en Latinoamérica. Objetivo: Analizar el pronóstico funcional y las tasas de mortalidad entre los participantes del Registro Latinoamericano de Enfermedad Vascular Cerebral (LASE). Métodos: Dieciocho centros de toda Latinoamérica recopilaron datos demográficos, factores de riesgo vascular, descripción clínica, pruebas auxiliares y resultados funcionales en la estancia hospitalaria de los pacientes incluidos entre enero de 2012 y enero de 2017. Todas estas variables se analizaron en función del resultado funcional al alta hospitalaria. Resultados: Se incluyeron 495 pacientes con ICH, que representan el 10.3% de todos los subtipos de enfermedad vascular cerebral en LASE. La mediana de estancia hospitalaria fue de 9 dias (rango intercuartil, 1-30); 285 (57.6%) fueron hombres (mediana de edad, 62 años) and 210 mujeres (mediana de edad, 65 años). Un mal resultado funcional (Escala modificada de Rankin, 3-6) fue observado en 214 (43.2%) pacientes, con un 62.5% de mujeres (p < 0.009). Se documento mortalidad en 12.5% de los pacientes con ICH. Las curvas de supervivencia de Kaplan-Meier presentaron diferencias en la mortalidad, con mayor frecuencia en pacientes > 80 años (HR 1.89, 95% IC 1.07-3.35, p = 0.028), con GCS < 8 (HR 0.19, 95% IC 0.11-0.33, p = < 0.001), irrupción ventricular (HR 1.88, 95% IC 1.09-3.24, p = 0.0282), y volumen del hematoma > 30 cc (HR 2.36, 95% IC 1.17-4.77, p = 0.016). Conclusiones: Nuestro estudio demuestra un mal pronóstico funcional en 43.2% de los pacientes con ICH, siendo los factores de riesgo de mayor mortalidad la edad mayor de 80 años, los valores más bajos de GCS y la irrupción ventricular en el LASE. Nuestro estudio colaborativo aporta información sustancial sobre los factores que influyen en la aparición, el pronóstico y los resultados de la ICH en Latinoamérica.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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