Early onset adolescent binge drinking is associated with reduced white matter integrity in post-9/11 adult veterans.
Adolescence represents a critical period of neural development during which binge drinking (BD) is prevalent. Though prior work has shown that white matter (WM) integrity is susceptible to damage from excessive alcohol intake in adults, the effect of early adolescent BD on WM health in adulthood rem...
| Publicado en: | Alcohol & Alcoholism Vol. 58; no. 6; pp. 662 - 672 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173587877&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173587877 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Nov2023 vid: 58 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 173587877 173587877 173587877 10.1093/alcalc/agad062 173587877 ppf: 662 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Early onset adolescent binge drinking is associated with reduced white matter integrity in post-9/11 adult veterans. aug: au: Knoff, Aubrey A Knight, Arielle R Salat, David H Bedi, Amrita Currao, Alyssa Fonda, Jennifer R McGlinchey, Regina E Fortier, Catherine B affil: Translational Research Center for TBI and Stress Disorders (TRACTS), VA Boston Healthcare System , 150 South Huntington Avenue, Boston, MA 02130 , United States sug: subj: Binge Drinking Complications White Matter Physiopathology Veterans In Adulthood Funding Source Human Male Female Adolescence Adult Descriptive Statistics Data Analysis Software Cross Sectional Studies T-Tests Chi Square Test Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Adolescence represents a critical period of neural development during which binge drinking (BD) is prevalent. Though prior work has shown that white matter (WM) integrity is susceptible to damage from excessive alcohol intake in adults, the effect of early adolescent BD on WM health in adulthood remains unknown. Veterans with a history of BD onset before age 15 [ n = 49; mean age = 31.8 years; early-onset adolescent binge drinkers (EBD)] and after age 15 [ n = 290; mean age = 32.2 years; late-onset adolescent binge drinkers (LBD)] were studied with diffusion tensor imaging. Group differences in fractional anisotropy (FA; movement of water molecules along the WM) and mean diffusivity (MD; average movement of water molecules) were examined as indices of WM integrity using FreeSurfer and FMRIB Software Library (FSL) processing streams. Lower FA and higher MD are thought to represent degradations in WM integrity. A reference group (RG) of social drinkers with no history of BD (n = 31) was used to provide comparative normative data. We observed widespread decreased FA and increased MD in EBDs, compared to LBDs, as well as decreased FA in the pars triangularis, lateral orbitofrontal cortex, superior frontal cortex, isthmus cingulate, and genu and splenium of the corpus callosum EBDs also had lower WM integrity compared to the RG. Adults who initiated BD during early adolescence demonstrated decreased FA and increased MD throughout the frontostriatal circuits that mediate inhibitory control and thus may result in impulsive behavior and a predisposition for developing alcohol use disorder during adulthood. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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