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Altered local spontaneous brain activity pattern in children with right-eye amblyopia of varying degrees: evidence from fMRI.

Purpose: To investigate the abnormal changes of local brain activity in children with right-eye amblyopia of varying degrees. Methods: Data of resting-state functional magnetic resonance imaging were collected from 16 children with severe amblyopia, 17 children with mild to moderate amblyopia, and 1...

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Published in:Neuroradiology Vol. 65; no. 12; pp. 1757 - 1767
Main Authors: Zhang, Xiaopan, Liu, Liang, Li, Yadong, Wang, Kejia, Zheng, Guangying, Zhang, Yong, Cheng, Jingliang, Wen, Baohong
Format: diagnostic images pictorial research tables/charts Journal Article
Published: Springer Nature Dec2023
Online Access:View this record in EBSCOhost
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      dt: Dec2023
      vid: 65
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00234-023-03221-x
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        atl: Altered local spontaneous brain activity pattern in children with right-eye amblyopia of varying degrees: evidence from fMRI.
      aug:
        au:
          Zhang, Xiaopan
          Liu, Liang
          Li, Yadong
          Wang, Kejia
          Zheng, Guangying
          Zhang, Yong
          Cheng, Jingliang
          Wen, Baohong
        affil: https://ror.org/056swr059 Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China
      sug:
        subj:
          Brain Physiology
          Eye Diseases
          Amblyopia
          Human
          Child
          Funding Source
          Magnetic Resonance Imaging Methods
          Visual Acuity
          Vision Disorders
          Child: 6-12 years
      ab: Purpose: To investigate the abnormal changes of local brain activity in children with right-eye amblyopia of varying degrees. Methods: Data of resting-state functional magnetic resonance imaging were collected from 16 children with severe amblyopia, 17 children with mild to moderate amblyopia, and 15 children with normal binocular vision. Local brain activity was analyzed using the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo). Results: There were extensive ALFF differences among the three groups in 10 brain regions. There were extensive differences in ReHo among the three groups in 11 brain regions. The ALFF and ReHo of the right orbital part of the middle frontal gyrus displayed a significantly positive correlation with the best-corrected visual acuity of the right eye, respectively. The ALFF value and ReHo value of the right orbital part of the middle frontal gyrus followed the pattern of normal control < mild to moderate amblyopia < severe amblyopia. Conclusion: This study demonstrated that there were changes in specific patterns of ALFF and ReHo in children with right-eye amblyopia of different degrees in brain regions performing visual sensorimotor and attentional control functions.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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