Involvement of the default mode network in patients with transient global amnesia: multilayer network.
Introduction: We aimed to investigate the alterations in the multilayer network in patients with transient global amnesia (TGA). Methods: We enrolled 124 patients with TGA and 80 healthy controls. Both patients with TGA and healthy controls underwent a three-teslar brain magnetic resonance imaging (...
| Publicado en: | Neuroradiology Vol. 65; no. 12; pp. 1729 - 1737 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173653983&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173653983 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Dec2023 vid: 65 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 173653983 173029386 173653983 173653983 10.1007/s00234-023-03241-7 173653983 ppf: 1729 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Involvement of the default mode network in patients with transient global amnesia: multilayer network. aug: au: Lee, Dong Ah Lee, Ho-Joon Park, Kang Min affil: https://ror.org/04xqwq985 Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-Ro 875, Haeundae-Gu, 48108, Busan, Republic of Korea sug: subj: Amnesia Default Mode Network Human Funding Source Magnetic Resonance Imaging Gray Matter Neural Networks (Computer) Male Female Middle Age Aged Comparative Studies Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: We aimed to investigate the alterations in the multilayer network in patients with transient global amnesia (TGA). Methods: We enrolled 124 patients with TGA and 80 healthy controls. Both patients with TGA and healthy controls underwent a three-teslar brain magnetic resonance imaging (MRI). A gray matter layer matrix was created using a morphometric similarity network derived from the T1-weighted imaging, and a white matter layer matrix was constructed using structural connectivity based on the diffusion tensor imaging. A multilayer network analysis was performed by applying graph theoretical analysis. Results: There were no significant differences in global network measures between the groups. However, several regions, related to the default mode network, showed significant differences in nodal network measures between the groups. Multi-richness in the left pars opercularis, multi-rich-club degree in the right posterior cingulate gyrus, and weighted multiplex participation in the right posterior cingulate gyrus were higher in patients with TGA compared with healthy controls (15.47 vs. 12.26, p = 0.0005; 41.68 vs. 37.16, p = 0.0005; 0.90 vs. 0.80, p = 0.0005; respectively). The multiplex core–periphery in the left precuneus was higher (0.96 vs. 0.84, p = 0.0005), whereas that in the transverse temporal gyrus was lower in patients with TGA compared with healthy controls (0.00 vs. 0.02, p = 0.0005). Conclusion: We newly find the alterations in the multilayer network in patients with TGA compared with healthy controls, which shows the involvement of the default mode network. These changes may be related to the pathophysiology of TGA. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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