Higher atherogenic risk in schoolchildren is associated with MTMR9 rs2293855 gene polymorphism and genetic score.
Childhood dyslipidaemia is associated with the occurrence of cardiovascular diseases in adulthood, so evaluating whether an individual has a genetic predisposition to this pathology is of great importance for early action of prevention and treatment. This study aimed to evaluate the association betw...
| Publicado en: | Nutrition Bulletin Vol. 48; no. 4; pp. 559 - 572 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173778216&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173778216 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14719827 F0S jtl: Nutrition Bulletin issn: 14719827 maglogo: Y pubinfo: dt: Dec2023 vid: 48 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 173778216 173357971 173778216 173778216 10.1111/nbu.12644 173778216 ppf: 559 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Higher atherogenic risk in schoolchildren is associated with MTMR9 rs2293855 gene polymorphism and genetic score. aug: au: Silva, Mariane Alves Resende, Cristina Maria Mendes Louro, Maíra Barros Ribeiro, Sarah Aparecida Vieira do Carmo Castro Franceschini, Sylvia Velasquez‐Melendez, Gustavo Alvarez‐Leite, Jacqueline Isaura Durso, Danielle Fernandes de Novaes, Juliana Farias affil: Faculty of Nutrition, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil sug: subj: Polymorphism, Genetic Hyperlipidemia Risk Factors Risk Assessment Hyperlipidemia Familial and Genetic Genetic Screening Pediatric Obesity Risk Factors Pediatric Obesity Familial and Genetic Human Funding Source Child Polymorphism, Single Nucleotide Brazil Cross Sectional Studies Child, Preschool Genotype Lipoproteins, HDL Cholesterol Lipoproteins, LDL Cholesterol Semi-Structured Interview Questionnaires Alleles Cardiovascular Risk Factors Surveys Sociodemographic Factors Economic Factors Life Style Anthropometry Body Composition Nonparametric Statistics Descriptive Statistics Comparative Studies Confidence Intervals Multiple Linear Regression Data Analysis Software Chi Square Test Male Female Child: 6-12 years Child, Preschool: 2-5 years Male Female ab: Childhood dyslipidaemia is associated with the occurrence of cardiovascular diseases in adulthood, so evaluating whether an individual has a genetic predisposition to this pathology is of great importance for early action of prevention and treatment. This study aimed to evaluate the association between the FTO (rs9939609), MC4R (rs17782313) and MTMR9 (rs2293855) polymorphisms, the obesity‐related genetic risk score and atherogenic risk in Brazilian children. This is a cross‐sectional study conducted in 544 children aged 4–9 years in the city of Viçosa, Minas Gerais state, Brazil. The single nucleotide polymorphisms rs9939609, rs17782313 and rs2293855, were identified by the system TaqMan SNP genotyping and the obesity‐related genetic risk score was determined. The lipid profile (serum total cholesterol [TC], high density lipoprotein [HDL] cholesterol, low density lipoprotein [LDL] cholesterol, triglycerides) was analysed and the atherogenic indices (Castelli I and II indices), atherogenic coefficient (AC), lipoprotein combined index (LCI) and plasma atherogenic index (PAI) were calculated. A semi‐structured questionnaire was applied, obtaining data on the sociodemographic, economic and lifestyle characteristics of the children. Weight and height measurements were performed in all children, and body composition was evaluated by Dual‐Energy X‐ray Absorptiometry (DXA). 55.5% of the sample had dyslipidaemia, while 28.5% of the sample had at least one polymorphism and 2.2% had three polymorphisms. Children with the AG/AA genotypes in the rs2293855 polymorphism had lower HDL cholesterol levels and higher TC/HDL cholesterol, LDL/HDL cholesterol ratios and AC. Those with one or more polymorphisms (rs9939609, rs17782313 and rs2293855) in the genetic risk score had lower HDL cholesterol levels and higher TC/HDL cholesterol ratios, AC, LCI and PAI. In conclusion, the risk allele of the rs2293855 polymorphism and a higher obesity‐related genetic risk score were positively associated with higher atherogenic risk in Brazilian children. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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