Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: an updated review.
Purpose: The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put the world in a medical crisis for the past three years; nearly 6.3 million lives have been diminished due to the virus outbreak. This review aims to update the recent findings on...
| Publicado en: | Infection Vol. 51; no. 6; pp. 1603 - 1619 |
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| Autores principales: | , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=173806141&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 173806141 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Dec2023 vid: 51 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 173806141 162347001 173806141 173806141 10.1007/s15010-023-02017-8 173806141 ppf: 1603 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: an updated review. aug: au: Dey, Amit Vaishak, K. Deka, Dikshita Radhakrishnan, Arun Kumar Paul, Sujay Shanmugam, Priyadarshini Daniel, Alice Peace Pathak, Surajit Duttaroy, Asim K. Banerjee, Antara affil: https://ror.org/0394w2w14 Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Kelambakkam, 603103, Chennai, TN, India sug: subj: COVID-19 Cytokine Release Syndrome Epigenomics Human SARS-CoV-2 Disease Outbreaks Mortality Morbidity Histones Proteins Interleukins MicroRNA Funding Source ab: Purpose: The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put the world in a medical crisis for the past three years; nearly 6.3 million lives have been diminished due to the virus outbreak. This review aims to update the recent findings on COVID-19 infections from an epigenetic scenario and develop future perspectives of epi-drugs to treat the disease. Methods: Original research articles and review studies related to COVID-19 were searched and analyzed from the Google Scholar/PubMed/Medline databases mainly between 2019 and 2022 to brief the recent work. Results: Numerous in-depth studies of the mechanisms used by SARS-CoV-2 have been going on to minimize the consequences of the viral outburst. Angiotensin-Converting Enzyme 2 receptors and Transmembrane serine protease 2 facilitate viral entry to the host cells. Upon internalization, it uses the host machinery to replicate viral copies and alter the downstream regulation of the normal cells, causing infection-related morbidities and mortalities. In addition, several epigenetic regulations such as DNA methylation, acetylation, histone modifications, microRNA, and other factors (age, sex, etc.) are responsible for the regulations of viral entry, its immune evasion, and cytokine responses also play a major modulatory role in COVID-19 severity, which has been discussed in detail in this review. Conclusion: Findings of epigenetic regulation of viral pathogenicity open a new window for epi-drugs as a possible therapeutical approach against COVID-19. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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