Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task.
Background: A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction er...
| Publicado en: | Psychological Medicine Vol. 53; no. 15; pp. 7106 - 7116 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174185333&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174185333 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Nov2023 vid: 53 iid: 15 pid: 15979 pub: Cambridge University Press artinfo: ui: 174185333 174185333 174185333 10.1017/S0033291723000521 174185333 ppf: 7106 ppct: 10 formats: tig: atl: Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task. aug: au: Fuentes-Claramonte, Paola Garcia-Leon, Maria Angeles Salgado-Pineda, Pilar Ramiro, Núria Soler-Vidal, Joan Torres, Maria Llanos Cano, Ramon Argila-Plaza, Isabel Panicali, Francesco Sarri, Carmen Jaurrieta, Núria Sánchez, Manel Boix-Quintana, Ester Albacete, Auria Maristany, Teresa Sarró, Salvador Raduà, Joaquim McKenna, Peter J. Salvador, Raymond Pomarol-Clotet, Edith affil: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain sug: subj: Schizophrenia Symptoms Dopamine Reward Task Performance and Analysis Human Female Male Adult Middle Age Prefrontal Cortex Psychotic Disorders DSM Magnetic Resonance Imaging Methods Brain Physiopathology Sociodemographic Factors Image Processing, Computer Assisted Comparative Studies Control Group Outcome Assessment Scales Linear Regression Descriptive Statistics Funding Source Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction error (RPE). Nevertheless, few functional imaging studies have examined if patients with negative symptoms show reduced RPE-associated activations. Methods: Matched groups of DSM-5 schizophrenia patients with high negative symptom scores (HNS, N = 27) or absent negative symptoms (ANS, N = 27) and healthy controls (HC, N = 30) underwent fMRI scanning while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Results: In the HC, whole-brain analysis revealed that RPE was positively associated with activation in the ventral striatum, the putamen, and areas of the lateral prefrontal cortex and orbitofrontal cortex, among other regions. Group comparison revealed no activation differences between the healthy controls and the ANS patients. However, compared to the ANS patients, the HNS patients showed regions of significantly reduced activation in the left ventrolateral and dorsolateral prefrontal cortex, and in the right lingual and fusiform gyrus. HNS and ANS patients showed no activation differences in ventral striatal or midbrain regions-of-interest (ROIs), but the HNS patients showed reduced activation in a left orbitofrontal cortex ROI. Conclusions: The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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