Application of a novel exposure limit approach for co-exposure of chemicals: a field study by in-vitro design.
This study has suggested an occupational exposure limit (OEL) based on the co-exposure approach in an iron-foundry industry. Respirable dust was collected in an iron casting industry using the NIOSH 0600 method. The DNA damage was obtained by comet assay. The lower confidence interval of the benchma...
| Publicado en: | International Journal of Environmental Health Research Vol. 33; no. 12; pp. 1269 - 1278 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174203825&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174203825 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Dec2023 vid: 33 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 174203825 157302869 174203825 174203825 10.1080/09603123.2022.2084513 174203825 ppf: 1269 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Application of a novel exposure limit approach for co-exposure of chemicals: a field study by in-vitro design. aug: au: Vahabi Shekarloo, Masoomeh Panjali, Zahra Mehrifar, Younes Ramezanifar, Soleiman Naziri, Seyed Husein Ghasemi Koozekonan, Aysa Moradpour, Zahra Zendehdel, Rezvan affil: Student Research Committee, Department of Occupational Health and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Occupational Exposure Adverse Effects Iron Metallurgy Adverse Effects Human Field Studies In Vitro Studies Air Pollutants Dust DNA Damage Biological Assay Confidence Intervals Cell Line Funding Source ab: This study has suggested an occupational exposure limit (OEL) based on the co-exposure approach in an iron-foundry industry. Respirable dust was collected in an iron casting industry using the NIOSH 0600 method. The DNA damage was obtained by comet assay. The lower confidence interval of the benchmark dose (BMDL) was employed for exposure limit evaluation. The estimated BMDL of the cell line was extrapolated to human subjects. Based on the Hill model, a BMDL 1.65 µg for chemical mixture has been estimated for the A549 cell line. According to uncertainty factors, permitted daily exposure (PDE) was predicted in humans. However, PDE of 3.9 μg/m3 was specified as the time-weighted average limit for toxic respirable dust in the casting industry. In this study, OEL for active respirable dust in the casting industry has been proposed. The industry-based standard for active respirable dust has been proposed for better management of co-exposure. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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