Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium.
Polychlorinated biphenyls (PCBs) were used in different industrial areas and banned due to their high toxicity. Aroclor 1254 (A1254), commercial PCB congener, accumulates in environment leading to high human exposure. A1254 may cause hepatotoxicity, metabolic and endocrine disorders. In our study, 3...
| Publicado en: | International Journal of Environmental Health Research Vol. 33; no. 12; pp. 1289 - 1305 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174203867&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174203867 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Dec2023 vid: 33 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 174203867 164242372 174203867 174203867 10.1080/09603123.2023.2223470 174203867 ppf: 1289 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium. aug: au: Balcı Özyurt, Aylin Erkekoğlu, Pınar Zeybek, Naciye Dilara Aşcı, Ali Yaman, Ünzile Oflaz, Ofcan Kızılgün, Murat İşcan, Evin Batur, Tuğçe Öztürk, Mehmet Koçer-Gümüşel, Belma affil: Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey sug: subj: Hepatotoxicity Drug Therapy Liver Drug Effects Selenium Therapeutic Use Polychlorinated Biphenyls Poisoning Environmental Pollutants Poisoning Models, Biological Animal Studies Rats Thyroid Antagonists Adverse Effects Polychlorinated Biphenyls Administration and Dosage Polychlorinated Biphenyls Adverse Effects Funding Source ab: Polychlorinated biphenyls (PCBs) were used in different industrial areas and banned due to their high toxicity. Aroclor 1254 (A1254), commercial PCB congener, accumulates in environment leading to high human exposure. A1254 may cause hepatotoxicity, metabolic and endocrine disorders. In our study, 3-week-old male rats were separated into 6 groups: C (0.15 mg/kg Se in diet); SeS (1 mg/kg Se in diet); SeD (0.05 mg/kg Se in diet); A1254 receiving groups (A; ASeS; ASeD) were given 10 mg/kg/day A1254 orally for last 15 days of feeding period with control, SeD or SeS diet, respectively, for 5 weeks. Histopathology, oxidant/antioxidant balance, apoptosis and cell cycle proteins (p53, p21) in liver were evaluated. Our results suggest that A1254 leads to changes in histology, oxidative stress and apoptosis. Selenium deficiency augments oxidative stress and apoptosis while selenium supplementation is partially protective. More mechanistic in vivo experiments are necessary for evaluation of hepatotoxicity of PCBs. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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