Non-albumin proteinuria marks tubular involvement and is associated with arterial stiffness in subjects affected by severe obesity.
Obesity is a well-established risk factor for kidney disease, and tubular damage can play a pivotal role in the development of obesity-related kidney damage. This study aimed to investigate the pathophysiological pathways involved in the development of non-albumin proteinuria (NAP), a marker of tubu...
| Publicado en: | Obesity Research & Clinical Practice Vol. 17; no. 6; pp. 485 - 492 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174295485&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174295485 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1871403X 3A05 jtl: Obesity Research & Clinical Practice issn: 1871403X maglogo: N pubinfo: dt: Nov2023 vid: 17 iid: 6 pid: 1004 pub: Elsevier B.V. artinfo: ui: 174295485 174295485 174295485 10.1016/j.orcp.2023.10.002 174295485 ppf: 485 ppct: 7 formats: tig: atl: Non-albumin proteinuria marks tubular involvement and is associated with arterial stiffness in subjects affected by severe obesity. aug: au: Moriconi, Diego Nannipieri, Monica Armenia, Silvia Taddei, Stefano Solini, Anna Bruno, Rosa Maria affil: Department of Clinical and Experimental Medicine, University of Pisa, Italy sug: subj: Albuminuria Etiology Proteinuria Complications Arterial Stiffness Physiology Obesity, Morbid Complications Obesity, Morbid Surgery Human Blood Pressure Lipoproteins, LDL Cholesterol Blood Obesity Pulse Wave Velocity Adverse Effects Bariatric Surgery Methods Kidney Function Tests Evaluation Kidney Physiology Glycated Hemoglobin Analysis Body Mass Index Cardiovascular Risk Factors Risk Assessment Scales Clinical Assessment Tools Comparative Studies ab: Obesity is a well-established risk factor for kidney disease, and tubular damage can play a pivotal role in the development of obesity-related kidney damage. This study aimed to investigate the pathophysiological pathways involved in the development of non-albumin proteinuria (NAP), a marker of tubular involvement, in a cohort of subjects with severe obesity and preserved kidney function. A total of 106 subjects with BMI ≥ 35 kg/m2 in waiting list for bariatric surgery underwent blood chemistry analysis including metabolic and lipid profile, vascular tests for cardiovascular risk stratification and a comprehensive assessment of kidney function, including renal resistive index (RRI) and NAP measurement. Nineteen patients with ACR ≥ 30 mg/g regardless of NAP values (ALB+), nineteen with NAP≥ 150 mg/g and albuminuria < 30 mg/g (iNAP) and sixty-eight without proteinuria (No-P) were found. Both ALB+ and iNAP groups exhibited a higher prevalence of hypertension and anti-hypertensive treatment compared to No-P, while the prevalence of diabetes was similar between groups. Concerning lipid profile, no differences in total, HDL and LDL cholesterol were found, while ALB+ patients had higher serum triglyceride levels than the other two groups. RRI and carotid-femoral pulse wave velocity (cf-PWV) was significantly higher in ALB+ and iNAP groups compared to No-P. Remarkably, cf-PWV remained still significant after adjustment for age, sex and MBP (p = 0.0004). In overall population, a multiple regression analysis showed that cf-PWV was an independent determinant of NAP in a model including age, sex, glycated hemoglobin, systolic and mean blood pressure (R2 =0.17, p = 0.031). iNAP subjects showed increased arterial stiffness comparable to that observed in ALB+ group, suggesting that they may represent a subgroup at higher cardiovascular risk, often unrecognized in clinical practice. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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