Bioreactors for Hematopoietic Stem Cell and Progenitor Expansion.

Objective: To describe the use of bioreactors for hematopoeitic stem cell and progenitor cell culture and comparing the various bioreactors to know which one is the best. Materials and Method: We conducted a data search on PubMed in December 18, 2021 and January 18, 2022. We used "Bioreactor" AND "H...

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Publicado en:International Medical Journal Vol. 30; no. 6; pp. 301 - 305
Autores principales: Aditya, Robby Nur, Pawitan, Jeanne Adiwinata
Formato: pictorial tables/charts Journal Article
Publicado: Japan International Cultural Exchange Foundation Dec2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2023
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      pub: Japan International Cultural Exchange Foundation
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        atl: Bioreactors for Hematopoietic Stem Cell and Progenitor Expansion.
      aug:
        au:
          Aditya, Robby Nur
          Pawitan, Jeanne Adiwinata
        affil: Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia
      sug:
        subj:
          Biotechnology Equipment and Supplies
          Hematopoietic Stem Cells
          Cell Culture Techniques Methods
          Biotechnology Classification
          Narratives
          Microfluidics
      ab: Objective: To describe the use of bioreactors for hematopoeitic stem cell and progenitor cell culture and comparing the various bioreactors to know which one is the best. Materials and Method: We conducted a data search on PubMed in December 18, 2021 and January 18, 2022. We used "Bioreactor" AND "Hematopoietic stem cell" OR "progenitor" as keywords. Data collection procedure: search results were filtered and selected so that only articles, which contained data about the type of bioreactor, mechanism of bioreactor, and cell source of HSC and progenitors, were used. Result and Discussion: The search yielded nine articles that were used to compose this narrative review. There are two main bioreactor classification, perfusion and stirred tank bioreactor. There are various models, which can be adapted easily according to research needs, such as microfluidic, hollow fibre, continuous perfusion and micro-cavity array bioreactors. Conclusion: Comparison between those bioreactors showed that perfusion bioreactor is more advantageous and widely used for research purposes that are related to HSCs and progenitors. This fact is due to the possibility of a simpler type and more benefits than stirred types.
      pubtype: Academic Journal
      doctype:
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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