Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review.
Background: Withania somnifera (WS), a popular medicinal plant of the Solanaceae family, contains active ingredients with antioxidant, anti-inflammatory, immunomodulatory, and anti-stress activities. However, its precise mechanisms of action and optimal use as a supplement are not yet fully understo...
| Publicado en: | Nutrients Vol. 15; no. 24; pp. 5015 - 5027 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
MDPI
Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174469880&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174469880 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Dec2023 vid: 15 iid: 24 pid: 97109 pub: MDPI artinfo: ui: 174469880 174469880 174469880 10.3390/nu15245015 174469880 ppf: 5015 ppct: 12 formats: tig: atl: Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review. aug: au: Della Porta, Matteo Maier, Jeanette A. Cazzola, Roberta affil: Department of Biomedical and Clinical Sciences, University of Milano, 20157 Milan, Italy sug: subj: Plants, Medicinal Therapeutic Use Plants, Medicinal Pharmacodynamics Plants, Medicinal Pharmacokinetics Hydrocortisone Drug Effects Stress Drug Therapy Treatment Outcomes Evaluation Human Plant Extracts Descriptive Statistics Systematic Review Embase PubMed Antioxidants Antiinflammatory Agents Stress Prevention and Control Medicine, Herbal Alkaloids Stress Management Methods ab: Background: Withania somnifera (WS), a popular medicinal plant of the Solanaceae family, contains active ingredients with antioxidant, anti-inflammatory, immunomodulatory, and anti-stress activities. However, its precise mechanisms of action and optimal use as a supplement are not yet fully understood. The objective of this systematic review is to assess the impact of WS supplementation on cortisol levels in stressed humans by analyzing clinical trials conducted prior to May 2023. Methods: The assessment was carried out following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) by exploring the databases of EMBASE, PubMed, Google Scholar, CENTRAL, and Scopus. Results: Of the 4788 articles identified, only 9 studies met the selection criteria. The selected studies varied in terms of design, results, formulations, dosages, and treatment duration (30–112 days), and involved subjects with varying degrees of stress. WS supplementation decreases cortisol secretion with no significant adverse effects. Nonetheless, none of the studies evaluated the potential impact of cortisol reduction on adrenal function and long-term effects. Conclusions: Brief-term supplementation with WS appears to have a stress-reducing effect in stressed individuals. However, since the long-term effects of WS supplementation are not yet fully understood, WS supplements should be used under medical supervision. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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