Association between the Serum Vitamin D Concentration and All-Cause and Cancer-Specific Mortality in Individuals with Cancer.
We aimed to explore the association between the serum 25-hydroxyvitamin D concentration and all-cause and cancer-specific mortality in 2,463 adult patients with cancer from the National Health and Nutrition Examination Survey 2007–2018. We linked mortality data from the survey to the National Death...
| Published in: | Nutrition & Cancer Vol. 76; no. 1; pp. 89 - 98 |
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| Main Authors: | , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174510481&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174510481 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2024 vid: 76 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 174510481 173684500 174510481 174510481 10.1080/01635581.2023.2279233 174510481 ppf: 89 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between the Serum Vitamin D Concentration and All-Cause and Cancer-Specific Mortality in Individuals with Cancer. aug: au: Bai, Yu Wen, Yong-qing Ma, Xu affil: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital and Institute, Beijing, China sug: subj: Vitamin D Deficiency Complications Cause of Death Risk Factors Neoplasms Mortality Vitamin D Blood Cancer Patients Psychosocial Factors Risk Assessment Evaluation Human Male Female Adult Middle Age Aged Multivariate Analysis Demography Life Style Diet Confidence Intervals Mortality Prevention and Control Kruskal-Wallis Test Analysis of Variance Chi Square Test Cox Proportional Hazards Model Data Analysis Software Descriptive Statistics Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: We aimed to explore the association between the serum 25-hydroxyvitamin D concentration and all-cause and cancer-specific mortality in 2,463 adult patients with cancer from the National Health and Nutrition Examination Survey 2007–2018. We linked mortality data from the survey to the National Death Index records up to December 31, 2019. During a median follow-up period of 70 months, 567 patients died, of whom 194 died due to cancer. Multivariate adjustment was performed for demographic characteristics, lifestyle, dietary factors, 25-hydroxyvitamin D testing period, and cancer site. Higher serum 25-hydroxyvitamin D concentrations up to 75 nmol/L significantly reduced the risk of all-cause and cancer-specific mortality. When 25-hydroxyvitamin D quartiles were compared, the multivariable-adjusted hazard ratios were 0.59 (95% confidence interval: 0.42, 0.84) for all-cause mortality (P for trend <0.001) and 0.48 (95% confidence interval: 0.29, 0.79) for cancer-specific mortality (P for trend = 0.037) in quartile 3 (79.3–99.2 nmol/L). A threshold of 75 nmol/L for serum 25-hydroxyvitamin D may represent an intervention target to reduce mortalities in patients with cancer, and maintaining 25(OH)D concentrations within range (79.3–99.2 nmol/L) is beneficial for reducing all-cause and cancer-specific mortality. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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