The emergence, implementation, and future growth of pharmacogenomics in psychiatry: a narrative review.
Psychotropic medication efficacy and tolerability are critical treatment issues faced by individuals with psychiatric disorders and their healthcare providers. For some people, it can take months to years of a trial-and-error process to identify a medication with the ideal efficacy and tolerability...
| Published in: | Psychological Medicine Vol. 53; no. 16; pp. 7983 - 7994 |
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| Main Authors: | , , , , |
| Format: | review tables/charts Journal Article |
| Published: |
Cambridge University Press
Dec2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174548499&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174548499 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Dec2023 vid: 53 iid: 16 pid: 15979 pub: Cambridge University Press artinfo: ui: 174548499 174548499 174548499 10.1017/S0033291723002817 174548499 ppf: 7983 ppct: 11 formats: tig: atl: The emergence, implementation, and future growth of pharmacogenomics in psychiatry: a narrative review. aug: au: Bousman, Chad A. Maruf, Abdullah Al Marques, Diogo Ferri Brown, Lisa C. Müller, Daniel J. affil: The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada sug: subj: Pharmacogenetics Methods Psychiatry Trends Genetic Variation Mental Disorders Drug Therapy Psychotropic Drugs Therapeutic Use Implementation Science Methods Algorithms Genomics Methods Signal Transduction Individualized Medicine Practice Guidelines Technology Methods ab: Psychotropic medication efficacy and tolerability are critical treatment issues faced by individuals with psychiatric disorders and their healthcare providers. For some people, it can take months to years of a trial-and-error process to identify a medication with the ideal efficacy and tolerability profile. Current strategies (e.g. clinical practice guidelines, treatment algorithms) for addressing this issue can be useful at the population level, but often fall short at the individual level. This is, in part, attributed to interindividual variation in genes that are involved in pharmacokinetic (i.e. absorption, distribution, metabolism, elimination) and pharmacodynamic (e.g. receptors, signaling pathways) processes that in large part, determine whether a medication will be efficacious or tolerable. A precision prescribing strategy know as pharmacogenomics (PGx) assesses these genomic variations, and uses it to inform selection and dosing of certain psychotropic medications. In this review, we describe the path that led to the emergence of PGx in psychiatry, the current evidence base and implementation status of PGx in the psychiatric clinic, and finally, the future growth potential of precision psychiatry via the convergence of the PGx-guided strategy with emerging technologies and approaches (i.e. pharmacoepigenomics, pharmacomicrobiomics, pharmacotranscriptomics, pharmacoproteomics, pharmacometabolomics) to personalize treatment of psychiatric disorders. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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