Progressive white matter degeneration in patients with spinocerebellar ataxia type 2.
Purpose: Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder characterized by cerebellar atrophy. However, studies to elucidate the longitudinal progression of the neuropathology are limited. We sought to identify brain macrostructural and microstructural alterations in...
| Publicado en: | Neuroradiology Vol. 66; no. 1; pp. 101 - 109 |
|---|---|
| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174559458&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174559458 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jan2024 vid: 66 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 174559458 173913905 174559458 174559458 10.1007/s00234-023-03260-4 174559458 ppf: 101 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Progressive white matter degeneration in patients with spinocerebellar ataxia type 2. aug: au: Tu, Ye Li, Zheng Xiong, Fei Gao, Feng affil: Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China sug: subj: Spinocerebellar Ataxias Classification Spinocerebellar Ataxias Radiography Brain Anatomy and Histology Disease Progression Diagnosis White Matter Radiography White Matter Pathology Magnetic Resonance Imaging Methods Human Prospective Studies Paired T-Tests Descriptive Statistics Brain Stem Pathology ab: Purpose: Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder characterized by cerebellar atrophy. However, studies to elucidate the longitudinal progression of the neuropathology are limited. We sought to identify brain macrostructural and microstructural alterations in patients with SCA2 using fixel-based analysis (FBA) to better understand its distribution patterns and progression. Methods: We enrolled 9 patients with SCA2 and 16 age- and gender-matched controls. Longitudinal clinical and imaging data were collected at baseline, and 3.5 years later. Fiber density (FD), fiber-bundle cross-section (FC), and a combination of FD and FC (FDC) were calculated. The paired t-test was used to examine longitudinal differences. The associations between fixel-based metrics and clinical variables were explored in SCA2 patients. Results: At baseline, patients with SCA2 displayed multiple white matter tracts with significantly decreased FD, FC, and FDC in the corticospinal tract, cerebellar peduncles, brainstem, corpus callosum, thalamus, striatum, and prefrontal cortex, compared to controls. Over time, many of these macrostructural and microstructural alterations progressed, manifesting lower FD, FC, and FDC in corticospinal tract, middle cerebellar peduncle, brainstem, striatum, fornix, and cingulum. No significant brain white matter alterations were found in the healthy controls over time. There was no association between the FBA-derived metrics and clinical variables in SCA2. Conclusion: This study provides evidence of brain macrostructural and microstructural alterations and of progression over time in SCA2. The FBA-derived metrics may serve as potential biomarkers of SCA2 progression. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|