Neuroquantification enhances the radiological evaluation of term neonatal hypoxic-ischaemic cerebral injuries.
Background: Injury patterns in hypoxic-ischaemic brain injury (HIBI) are well recognised but there are few studies evaluating cerebral injury using neuroquantification models. Objectives: Quantification of brain volumes in a group of patients with clinically determined cerebral palsy. Method: In thi...
| Publicado en: | South African Journal of Radiology Vol. 27; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
African Online Scientific Information System PTY LTD
2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174668907&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174668907 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1027202X 39WP jtl: South African Journal of Radiology issn: 1027202X maglogo: N pubinfo: dt: 2023 vid: 27 iid: 1 pid: 56831 pub: African Online Scientific Information System PTY LTD place: , <Blank> artinfo: ui: 174668907 174668907 174668907 10.4102/sajr.v27i1.2728 174668907 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neuroquantification enhances the radiological evaluation of term neonatal hypoxic-ischaemic cerebral injuries. aug: au: Misser, Shalendra K. Mchunu, Nobuhle Lotz, Jan W. Kjonigsen, Lisa Ulug, Aziz Archary, Moherndran affil: Department of Radiology, Lake Smit and Partners Inc., Durban, South Africa sug: subj: Cerebral Palsy Diagnosis Hypoxia-Ischemia, Brain, Neonatal Radiography Software Utilization Human Female Male Child Retrospective Design Magnetic Resonance Imaging Methods Thalamus Brain Stem Hippocampus Amygdala Artificial Intelligence Cerebral Palsy Radiography Statistical Significance Kruskal-Wallis Test Analysis of Variance Mann-Whitney U Test Data Analysis Software Descriptive Statistics Child: 6-12 years Female Male ab: Background: Injury patterns in hypoxic-ischaemic brain injury (HIBI) are well recognised but there are few studies evaluating cerebral injury using neuroquantification models. Objectives: Quantification of brain volumes in a group of patients with clinically determined cerebral palsy. Method: In this retrospective study, 297 children with cerebral palsy were imaged for suspected HIBI with analysis of various cerebral substrates. Of these, 96 children over the age of 3 years with a clinical diagnosis of cerebral palsy and abnormal MRI findings underwent volumetric analyses using the NeuroQuant® software solution. The spectrum of volumetric changes and the differences between the various subtypes (and individual subgroups) of HIBI were compared. Results: Compared with the available normative NeuroQuant® database, the average intracranial volume was reduced to the 1st percentile in all patient groups (p < 0.001). Statistically significant differences were observed among the types and subgroups of HIBI. Further substrate volume reductions were identified and described involving the thalami, brainstem, hippocampi, putamina and amygdala. The combined volumes of five regions of interest (frontal pole, putamen, hippocampus, brainstem and paracentral lobule) were consistently reduced in the Rolandic basal ganglia-thalamus (RBGT) subtype. Conclusion: This study determined a quantifiable reduction of intracranial volume in all subtypes of HIBI and predictable selective cerebral substrate volume reduction in subtypes and subgroups. In the RBGT subtype, a key combination of five substrate injuries was consistently noted, and thalamic, occipital lobe and brainstem volume reduction was also significant when compared to the watershed subtype. Contribution: This study demonstrates the value of integrating an artificial intelligence programme into the radiologists' armamentarium serving to quantify brain injuries more accurately in HIBI. Going forward this will be an inevitable evolution of daily radiology practice in many fields of medicine, and it would be beneficial for radiologists to embrace these technological innovations. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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