Cholinesterase, α-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of Rinorea oblongifolia C.H. Wright (Violaceae).
From Rinorea oblongifolia fruits, 3-Nor-4b-friedelan-24-ol (1) and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (4), new derivatives alongside, 28-hydroxyfriedelan-3-one (2), friedelin (3), 3,3',4,4',5'-pentamethylcoruleoellagic acid (5), hexamethylcoruleoellagic acid (6), 3',4...
| Publicado en: | Natural Product Research Vol. 37; no. 24; pp. 4169 - 4181 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174701573&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174701573 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: 2023 vid: 37 iid: 24 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 174701573 161763505 10.1080/14786419.2023.2176491 174701573 ppf: 4169 ppct: 12 formats: tig: atl: Cholinesterase, α-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of Rinorea oblongifolia C.H. Wright (Violaceae). aug: au: Munvera, Aristide Mfifen Ngenge, Tamfu Alfred Ouahouo, Blandine Marlyse Wache Kucukaydin, Selcuk Nyemb, Jean Noel Mafo, Marcelle Aude Fokam Tchapo, Emar Carlain Djappa Mkounga, Pierre Nkengfack, Augustin Ephrem affil: Department of Organic Chemistry, Faculty of Science, The University of Yaounde I, Yaounde, Cameroon sug: ab: From Rinorea oblongifolia fruits, 3-Nor-4b-friedelan-24-ol (1) and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (4), new derivatives alongside, 28-hydroxyfriedelan-3-one (2), friedelin (3), 3,3',4,4',5'-pentamethylcoruleoellagic acid (5), hexamethylcoruleoellagic acid (6), 3',4,4',5,5'-pentamethylcoruleoellagic acid (7), and fatty compounds 8-11 were isolated and characterized using HRESIMS, EIMS, 1D and 2D NMR. In vitro enzyme inhibition of compounds 1, 2, 4, 5, 6 and 7 were evaluated on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), a-glucosidase, urease and tyrosinase. Against AChE and BChE, the phenolic compounds 4, 5, 6, and 7 had good activity probably due to the phenolic nature and methoxy substituents. Compounds 4, 5, 6 and 7 exhibited good a-glucosidase inhibition especially compound 4 whose IC50 = 42.45 ± 0.46 mg/mL was close that of acarbose (IC50 = 20.52 ± 0.84 mg/mL) standard drug. Urease and tyrosinase were appreciably inhibited by the compounds. Overall results of enzyme inhibitory assays indicate Rinorea oblongifolia, fruits and its constituents as potential remedy for enzymatic disorders. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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