Therapeutic misunderstandings in modern research.
Clinical trials play a crucial role in generating evidence about healthcare interventions and improving outcomes for current and future patients. For individual trial participants, however, there are inevitably trade‐offs involved in clinical trial participation, given that trials have traditionally...
| Published in: | Bioethics Vol. 38; no. 2; pp. 138 - 153 |
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| Main Authors: | , , , , , |
| Format: | Article |
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Wiley-Blackwell
Feb2024
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=174779888&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 174779888 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 02699702 6PJ jtl: Bioethics issn: 02699702 maglogo: Y pubinfo: dt: Feb2024 vid: 38 iid: 2 pid: 480 pub: Wiley-Blackwell artinfo: ui: 174779888 10.1111/bioe.13241 ppf: 138 ppct: 15 formats: tig: atl: Therapeutic misunderstandings in modern research. aug: au: Heynemann, Sarah Lipworth, Wendy McLachlan, Sue‐Anne Philip, Jennifer John, Tom Kerridge, Ian affil: Sydney Health Ethics, Faculty of Medicine and Health, The University of Sydney, Sydney New South Wales,, Australia Department of Philosophy, Macquarie University, Sydney New South Wales,, Australia Department of Medical Oncology, St Vincent's Hospital, Melbourne Victoria,, Australia Department of Medicine, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne Victoria,, Australia Department of Palliative Care, St Vincent's Hospital, Melbourne Victoria,, Australia Department of Palliative Care, Peter MacCallum Cancer Centre, Melbourne Victoria,, Australia Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne Victoria,, Australia Sir Peter MacCallum Department of Medical Oncology, The University of Melbourne, Melbourne Victoria,, Australia Haematology Department, Royal North Shore Hospital, Sydney New South Wales,, Australia su: Occupational roles Human research subjects Clinical trials Research ethics Informed consent (Medical law) Communication Bioethics Patient selection Research methodology Tumors sug: subj: Occupational roles Human research subjects Clinical trials Research ethics Informed consent (Medical law) Communication Bioethics Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) Patient selection Research methodology Tumors keyword: adaptive clinical trial Bayes theorem clinical trials informed consent research ethics therapeutic misconception adaptive clinical trial Bayes theorem clinical trials informed consent research ethics therapeutic misconception ab: Clinical trials play a crucial role in generating evidence about healthcare interventions and improving outcomes for current and future patients. For individual trial participants, however, there are inevitably trade‐offs involved in clinical trial participation, given that trials have traditionally been designed to benefit future patient populations rather than to offer personalised care. Failure to understand the distinction between research and clinical care and the likelihood of benefit from participation in clinical trials has been termed the 'therapeutic misconception'. The evolution of the clinical trials landscape, including greater integration of clinical trials into healthcare and development of novel trial methodologies, may reinforce the significance of the therapeutic misconception and other forms of misunderstanding while at the same time (paradoxically) challenging its salience. Using cancer clinical trials as an exemplar, we describe how methodological changes in early‐ and late‐phase clinical trial designs, as well as changes in the design and delivery of healthcare, impact upon the therapeutic misconception. We suggest that this provides an impetus to re‐examine the ethics of clinical research, particularly in relation to trial access, participant selection, communication and consent, and role delineation. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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