Cortical thickness abnormalities in autism spectrum disorder.
The pathological mechanism of autism spectrum disorder (ASD) remains unclear. Nowadays, surface-based morphometry (SBM) based on structural magnetic resonance imaging (sMRI) techniques have reported cortical thickness (CT) variations in ASD. However, the findings were inconsistent and heterogeneous....
| Publicado en: | European Child & Adolescent Psychiatry Vol. 33; no. 1; pp. 65 - 78 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174972280&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174972280 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jan2024 vid: 33 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 174972280 160903123 174972280 174972280 10.1007/s00787-022-02133-0 174972280 ppf: 65 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cortical thickness abnormalities in autism spectrum disorder. aug: au: Shen, Liancheng Zhang, Junqing Fan, Shiran Ping, Liangliang Yu, Hao Xu, Fangfang Cheng, Yuqi Xu, Xiufeng Yang, Chunyan Zhou, Cong affil: Department of Psychiatry, Shandong Daizhuang Hospital, Jining, China sug: subj: Autism Spectrum Disorder Pathology Cerebral Cortex Abnormalities Cerebral Cortex Radiography Tomography, X-Ray Computed Brain Mapping Human Systematic Review Meta Analysis Funding Source Prefrontal Cortex Abnormalities Cerebral Cortical Thinning Adult Age Factors Magnetic Resonance Imaging Neuroradiography Adult: 19-44 years ab: The pathological mechanism of autism spectrum disorder (ASD) remains unclear. Nowadays, surface-based morphometry (SBM) based on structural magnetic resonance imaging (sMRI) techniques have reported cortical thickness (CT) variations in ASD. However, the findings were inconsistent and heterogeneous. This current meta-analysis conducted a whole-brain vertex-wise coordinate‐based meta‐analysis (CBMA) on CT studies to explore the most noticeable and robust CT changes in ASD individuals by applying the seed-based d mapping (SDM) program. A total of 26 investigations comprised 27 datasets were included, containing 1,635 subjects with ASD and 1470 HC, along with 94 coordinates. Individuals with ASD exhibited significantly altered CT in several regions compared to HC, including four clusters with thicker CT in the right superior temporal gyrus (STG.R), the left middle temporal gyrus (MTG.L), the left anterior cingulate/paracingulate gyri, the right superior frontal gyrus (SFG.R, medial orbital parts), as well as three clusters with cortical thinning including the left parahippocampal gyrus (PHG.L), the right precentral gyrus (PCG.R) and the left middle frontal gyrus (MFG.L). Adults with ASD only demonstrated CT thinning in the right parahippocampal gyrus (PHG.R), revealed by subgroup meta-analyses. Meta-regression analyses found that CT in STG.R was positively correlated with age. Meanwhile, CT in MFG.L and PHG.L had negative correlations with the age of ASD individuals. These results suggested a complicated and atypical cortical development trajectory in ASD, and would provide a deeper understanding of the neural mechanism underlying the cortical morphology in ASD. pubtype: Academic Journal doctype: diagnostic images meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|