Electroconvulsive therapy improves hematological inflammatory markers in bipolar disorder.
Background: Immune dysfunction and inflammation participate in the pathophysiology of bipolar disorder (BD). Abnormal levels of inflammatory markers, namely, red cell distribution width (RDW) and platelet distribution width (PDW), were detected in BD. Electroconvulsive therapy (ECT) for various ment...
| Publicado en: | Psychopharmacology Vol. 241; no. 2; pp. 351 - 358 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174972925&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174972925 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2024 vid: 241 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 174972925 173800745 10.1007/s00213-023-06491-8 174972925 ppf: 351 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Electroconvulsive therapy improves hematological inflammatory markers in bipolar disorder. aug: au: Ali, Eman Embaby, Ahmed Arafa, Shaymaa M. Elbana, Ahmed Kamal Ghazala, Mohamed Ibrahim, Doaa affil: https://ror.org/053g6we49 Psychiatry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt sug: ab: Background: Immune dysfunction and inflammation participate in the pathophysiology of bipolar disorder (BD). Abnormal levels of inflammatory markers, namely, red cell distribution width (RDW) and platelet distribution width (PDW), were detected in BD. Electroconvulsive therapy (ECT) for various mental disorders including BD was linked to changes in these inflammatory mediators. Hence, we aimed to assess the impact of ECT on PDW and RDW in patients with BD. Methods: Seventy-two patients aged ≥ 16 were enrolled in the current prospective cohort study over 6 months, diagnosed as BD based on DSM-IV and indicated for ECT and complete blood count (CBC) drawn pre-ECT and after four ECT sessions. Results: By the end of the ECT sessions, we noticed a significant elevation in PDW with lowering in RDW levels. However, no significant differences were detected before and after ECT regarding platelet (PLTs) count, mean platelet volume (MPV), and Plateletcrit (PCT). Conclusion: ECT seems to improve the CBC-derived inflammatory markers (RDW and PDW) subsequently, improving the underlying inflammatory process in BD without disturbing PLT homeostasis which support its anti-inflammatory role in BD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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