Aberrant Brain Dynamics in Schizophrenia During Working Memory Task: Evidence From a Replication Functional MRI Study.
Background and Hypothesis The integration of information that typifies working memory (WM) operation requires a flexible, dynamic functional relationship among brain regions. In schizophrenia, though WM capacity is prominently impaired at higher loads, the mechanistic underpinnings are unclear. As a...
| Publicado en: | Schizophrenia Bulletin Vol. 50; no. 1; pp. 96 - 107 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts tracings Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174979547&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174979547 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: Jan2024 vid: 50 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 174979547 174979547 174979547 10.1093/schbul/sbad032 174979547 ppf: 96 ppct: 11 formats: tig: atl: Aberrant Brain Dynamics in Schizophrenia During Working Memory Task: Evidence From a Replication Functional MRI Study. aug: au: Wang, Feiwen Liu, Zhening Ford, Sabrina D Deng, Mengjie Zhang, Wen Yang, Jie Palaniyappan, Lena affil: Department of Psychiatry, The Second Xiangya Hospital of Central South University , Changsha, Hunan , China sug: subj: Schizophrenia Physiopathology Brain Physiopathology Memory, Short Term Evaluation Task Performance and Analysis Magnetic Resonance Imaging Methods Functional Connectivity Cognition Human Comparative Studies Schizophrenia Symptoms Psychiatric Patients Cluster Analysis Temporal Lobe Physiopathology Basal Ganglia Physiopathology Descriptive Statistics Male Female Adolescence Adult China Funding Source Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Background and Hypothesis The integration of information that typifies working memory (WM) operation requires a flexible, dynamic functional relationship among brain regions. In schizophrenia, though WM capacity is prominently impaired at higher loads, the mechanistic underpinnings are unclear. As a result, we lack convincing cognitive remediation of load-dependent deficits. We hypothesize that reduced WM capacity arises from a disruption in dynamic functional connectivity when patients face cognitive demands. Study Design We calculate the dynamic voxel-wise degree centrality (dDC) across the functional connectome in 142 patients with schizophrenia and 88 healthy controls (HCs) facing different WM loads during an n-back task. We tested associations of the altered variability in dDC and clinical symptoms and identified intermediate connectivity configurations (clustered states) across time during WM operation. These analyses were repeated in another independent dataset of 169 subjects (102 with schizophrenia). Study Results Compared with HCs, patients showed an increased dDC variability of supplementary motor area (SMA) for the "2back vs. 0back" contrast. This instability at the SMA seen in patients correlated with increased positive symptoms and followed a limited "U-shape" pattern at rest-condition and 2 loads. In the clustering analysis, patients showed reduced centrality in the SMA, superior temporal gyrus, and putamen. These results were replicated in a constrained search in the second independent dataset. Conclusions Schizophrenia is characterized by a load-dependent reduction of stable centrality in SMA; this relates to the severity of positive symptoms, especially disorganized behaviour. Restoring SMA stability in the presence of cognitive demands may have a therapeutic effect in schizophrenia. pubtype: Academic Journal doctype: diagnostic images research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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