Single-locus and Haplotype Associations of GRIN2B Gene with Autism Spectrum Disorders and the Demographic and Clinical Characteristics of Patients in Guilan, Iran.
Autism spectrum disorders (ASDs) are described as generalized developmental disorders, with an average age of onset of 36 months. Genetic and environmental factors may contribute to this multifactorial disorder. The present study aimed to investigate the association of three GRIN2B polymorphisms, in...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 54; no. 2; pp. 607 - 615 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175021330&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175021330 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2024 vid: 54 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175021330 160280518 175021330 175021330 10.1007/s10803-022-05818-2 175021330 ppf: 607 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Single-locus and Haplotype Associations of GRIN2B Gene with Autism Spectrum Disorders and the Demographic and Clinical Characteristics of Patients in Guilan, Iran. aug: au: Pouyan Mehr, Donya Faraji, Niloofar Rezaei, Sajjad Keshavarz, Parvaneh affil: https://ror.org/04ptbrd12 Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran sug: subj: Autism Spectrum Disorder In Infancy and Childhood Haplotypes Evaluation Genome Gene Expression Polymorphism, Genetic Demography Child Development Receptors, Cell Surface Human Male Female Child Iran Age of Onset Phenotype Genotype Genes, Recessive Control Group Alleles Polymerase Chain Reaction Mutation DNA Demethylation Descriptive Statistics Child: 6-12 years Male Female ab: Autism spectrum disorders (ASDs) are described as generalized developmental disorders, with an average age of onset of 36 months. Genetic and environmental factors may contribute to this multifactorial disorder. The present study aimed to investigate the association of three GRIN2B polymorphisms, including rs1019385, rs1024893, and rs3764028, with ASDs. Based on the results, there was a significant difference regarding the genotype frequency of rs3764028 polymorphism between the control and case (ASD) groups (P = 0.027). According to the recessive model, this variant was associated with ASDs (P = 0.23). None of the eight haplotype models with frequencies above 0.5 showed significant differences between the case and control groups in terms of allelic frequency. The present results showed that the rs376028 variant was directly related to the phenotypic symptoms of ASDs. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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