Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome.
Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natur...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 54; no. 2; pp. 725 - 738 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175021332&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175021332 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2024 vid: 54 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175021332 160460406 175021332 175021332 10.1007/s10803-022-05821-7 175021332 ppf: 725 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome. aug: au: Kaufmann, Walter E. Raspa, Melissa Bann, Carla M. Gable, Julia M. Harris, Holly K. Budimirovic, Dejan B. Lozano, Reymundo Berry-Kravis, Elizabeth Velinov, Milen Talboy, Amy L Sherman, Stephanie L Kaufmann, Walter E Schuster, Marcy Tartaglia, Nicole Filipink, Robyn A Budimirovic, Dejan B Barbouth, Deborah Lightbody, Amy Reiss, Allan Delahunty, Carol M affil: Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, 30322, Atlanta, GA, USA sug: subj: Fragile X Syndrome Neurobehavioral Manifestations Evaluation Structural Equation Modeling Utilization Human Funding Source Male Female Child Child, Preschool Child Behavior Cross Sectional Studies Sleep Disorders Sensation Disorders Autism Spectrum Disorder Intellectual Disability Checklists Scales Questionnaires Child: 6-12 years Child, Preschool: 2-5 years Male Female ab: Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natural history study, to identify behavioral subtypes by latent class analysis. Input included co-occurring behavioral conditions, sleep and sensory problems, autistic behavior scales (SCQ, SRS-2), and the Aberrant Behavior Checklist revised for FXS (ABCFX). A 5-class solution yielded the most clinically meaningful, pharmacotherapy independent behavioral groups with distinctive SCQ, SRS-2, and ABCFX profiles, and adequate non-overlap (≥ 71%): "Mild" (31%), "Moderate without Social Impairment" (32%), "Moderate with Social Impairment" (7%), "Moderate with Disruptive Behavior" (20%), and "Severe" (9%). Our findings support FXS subtyping, for improving clinical management and therapeutic development. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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