Severity of Autism Spectrum Disorder Symptoms Associated with de novo Variants and Pregnancy-Induced Hypertension.
Genetic factors, particularly, de novo variants (DNV), and an environment factor, exposure to pregnancy-induced hypertension (PIH), were reported to be associated with risk of autism spectrum disorder (ASD); however, how they jointly affect the severity of ASD symptom is unclear. We assessed the sev...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 54; no. 2; pp. 749 - 765 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175021333&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175021333 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2024 vid: 54 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175021333 160485336 175021333 175021333 10.1007/s10803-022-05824-4 175021333 ppf: 749 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Severity of Autism Spectrum Disorder Symptoms Associated with de novo Variants and Pregnancy-Induced Hypertension. aug: au: Wang, Xiaomeng Ling, Zhengbao Luo, Tengfei Zhou, Qiao Zhao, Guihu Li, Bin Xia, Kun Li, Jinchen affil: Department of Geriatrics, Xiangya Hospital, Central South University, 41008, Changsha, Hunan, China sug: subj: Autism Spectrum Disorder Pathology Severity of Illness Risk Assessment Pregnancy-Induced Hypertension Complications Mutation Human Pregnancy Female Funding Source Phenotype Linear Regression Genotype Cognition Signal Transduction Proteins Catabolism Female ab: Genetic factors, particularly, de novo variants (DNV), and an environment factor, exposure to pregnancy-induced hypertension (PIH), were reported to be associated with risk of autism spectrum disorder (ASD); however, how they jointly affect the severity of ASD symptom is unclear. We assessed the severity of core ASD symptoms affected by functional de novo variants or PIH. We selected phenotype data from Simon's Simplex Collection database, used genotypes from previous studies, and created linear regression models. We found that ASD patients carrying DNV with PIH exposure had increased adaptive and cognitive ability, decreased social problems, and enhanced repetitive behaviors; however, there was no difference in patients without DNV between those with or without PIH exposure. In addition, the DNV genes carried by patients exposed to PIH were enriched in ubiquitin-dependent proteolytic processes, highlighting how candidate genes in pathways and environments interact. The results indicate the joint contribution of DNV and PIH to ASD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|